Propafenone

Research use only, not for human use.

An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.

An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.

Propafenone (5-25 μM) inhibits esophageal squamous cell carcinoma (ESCC) cell proliferation.Propafenone causes mitochondrial dysfunction by a decreased mitochondrial membrane potential and reduced expression of Bcl-xL and Bcl-2. Propafenone (10 and 20 μm) treatment significantly down regulates the expression levels of the anti-apoptotic proteins Bcl-xL and Bcl-2 in ESCC cells. Propafenone also reduces expression of p-ERK. Cell Proliferation Assay Cell Line:The human ESCC cell lines KYSE30, KYSE150 and KYSE270 Concentration:5, 10, 15, 20, and 25 μm Incubation Time:24, 48, and 72 hours Result:Gradually decreased cell proliferation over time and potently inhibited cell proliferation with increasing concentrations in KYSE30, KYSE150 and KYSE270 cells.Western Blot Analysis Cell Line:The human ESCC cell lines KYSE30, KYSE150 and KYSE270 Concentration:0, 10, and 20 μm Incubation Time:72 hours Result:Significant downregulation of Bcl-xL and Bcl-2 expression levels was observed.

Propafenone (20 mg/kg; intraperitoneal injection every other day) markedly suppresses the tumor burden with a decrease of 69.2%.Propafenone also significantly inhibits tumor cell proliferation (mean index decreased from 56.3±6.7% in the DMSO-treated group to 20.7±5.1% in the 10 mg/kg propafenone-treated group and 11.3±4.0% in the 20 mg/kg propafenone-treated group). Animal Model:Female BALB/c nude mice bearing KYSE270-derived xenografts (6-8 weeks)Dosage:10 mg/kg or 20 mg/kg Administration:Intraperitoneally injected Result:Exerted a significantly inhibitory effect on the growth of tumor xenografts.

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Endocrinology/Hormones

MRP

MRP1| Potassium Channel| Sodium Channel

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54063-53-5

341.44

C21H27NO3

>98% (HPLC)

Water: 93.28 mg/L

CCCNCC(O)COC1=CC=CC=C1C(=O)CCC1=CC=CC=C1

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(-20℃)

With Ice Pack

≥ 2 years