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Progabide

CAS No. 62666-20-0

Progabide( SL 76002 | Halogabide | Gabren | Gabrene )

Catalog No. M26795 CAS No. 62666-20-0

Progabide is an agonist of the gamma-aminobutyric acid receptor.

Progabide is an agonist of the gamma-aminobutyric acid receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Progabide
  • Note
    Research use only, not for human use.
  • Brief Description
    Progabide is an agonist of the gamma-aminobutyric acid receptor.
  • Description
    Progabide is an agonist of the gamma-aminobutyric acid receptor.(In Vivo):Progabide ( 50, 100 and 200 mg/kg) given IP to male Wistar rats enhance the plasma corticosterone levels by 244, 365, and 476% respectively (t=6.44 to12.55, p<0.01). Progabide (10 mg/kg) fails to change the concentration of corticosterone in plasma (t=0.76, N.S.). The increased plasma corticosterone level induced by administration of 200 mg/kg Progabide is evident 30 (t=2.625, p<0.05), 60 (t=13.13, p<0.001) and 120 min (t=4.07, p<0.01) after drug injection, but returns to the control value 240 min after drug injection (t=0.86, N.S.). Compare with the corresponding control, The greatest corticosterone rise is reached 60 min following the administration of Progabide.
  • In Vitro
    ——
  • In Vivo
    Progabide is a gamma-aminobutyric acid receptor (GABA) agonist. Doses of 50, 100 and 200 mg/kg Progabide given IP to male Wistar rats increase the plasma corticosterone levels by 244, 365 and 476% respectively (t=6.44 to12.55, p<0.01). 10 mg/kg of Progabide fails to change the concentration of corticosterone in plasma (t=0.76, N.S.). The increased plasma corticosterone level induced by administration of 200 mg/kg Progabide is evident 30 (t=2.625, p<0.05), 60 (t=13.13, p<0.001) and 120 min (t=4.07, p<0.01) after drug injection, but returns to the control value 240 min after drug injection (t=0.86, N.S.). The greatest corticosterone rise (compare with the corresponding control) is reached 60 min following the administration of Progabide.
  • Synonyms
    SL 76002 | Halogabide | Gabren | Gabrene
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Kv2.2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    62666-20-0
  • Formula Weight
    334.78
  • Molecular Formula
    C17H16ClFN2O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (746.78 mM)
  • SMILES
    NC(=O)CCC\N=C(\c1ccc(Cl)cc1)c1cc(F)ccc1O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Herrington J, et al. Identification of novel and selective Kv2 channel inhibitors. Mol Pharmacol. 2011 Dec;80(6):959-64.
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