Progabide

Research use only, not for human use.

Progabide is an agonist of the gamma-aminobutyric acid receptor.

Progabide is an agonist of the gamma-aminobutyric acid receptor.(In Vivo):Progabide ( 50, 100 and 200 mg/kg) given IP to male Wistar rats enhance the plasma corticosterone levels by 244, 365, and 476% respectively (t=6.44 to12.55, p<0.01). Progabide (10 mg/kg) fails to change the concentration of corticosterone in plasma (t=0.76, N.S.). The increased plasma corticosterone level induced by administration of 200 mg/kg Progabide is evident 30 (t=2.625, p<0.05), 60 (t=13.13, p<0.001) and 120 min (t=4.07, p<0.01) after drug injection, but returns to the control value 240 min after drug injection (t=0.86, N.S.). Compare with the corresponding control, The greatest corticosterone rise is reached 60 min following the administration of Progabide.

SL 76002; Halogabide; Gabren; Gabrene

Others

Other Targets

Kv2.2

——

——

62666-20-0

334.8

C17H16ClFN2O2

>98% (HPLC)

——

NC(=O)CCC\N=C(\c1ccc(Cl)cc1)c1cc(F)ccc1O

——

(-20℃)

With Ice Pack

≥ 2 years