Poziotinib

CAS No. 1092364-38-9

Poziotinib ( HM781-36B;NOV120101 )

Catalog No. M10347 CAS No. 1092364-38-9

Poziotinib (HM781-36B, NOV120101) is an irreversible pan-HER inhibitor with IC50 of 3.2/5.3 nM/23.5 nM for HER1/HER2/HER4.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 45 In Stock
5MG 81 In Stock
10MG 105 In Stock
25MG 243 In Stock
50MG 372 In Stock
100MG 554 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Poziotinib
  • Note
    Research use only, not for human use.
  • Brief Description
    Poziotinib (HM781-36B, NOV120101) is an irreversible pan-HER inhibitor with IC50 of 3.2/5.3 nM/23.5 nM for HER1/HER2/HER4.
  • Description
    Poziotinib (HM781-36B, NOV120101) is an irreversible pan-HER inhibitor with IC50 of 3.2/5.3 nM/23.5 nM for HER1/HER2/HER4; inhibits phosphorylation of HER family and downstream signaling molecules, and induced apoptosis and G1 arrest; exerts synergistic effects with chemotherapeutic agents.Breast Cancer Phase 2 Clinical
  • Synonyms
    HM781-36B;NOV120101
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    HER1;HER2;HER4
  • Research Area
    Cancer
  • Indication
    Breast Cancer

Chemical Information

  • CAS Number
    1092364-38-9
  • Formula Weight
    491.34
  • Molecular Formula
    C23H21Cl2FN4O3
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C=CC(N1CCC(OC2=CC3=C(NC4=CC=C(Cl)C(Cl)=C4F)N=CN=C3C=C2OC)CC1)=O
  • Chemical Name
    2-Propen-1-one, 1-[4-[[4-[(3,4-dichloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-1-piperidinyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nam HJ, et al. Cancer Lett. 2011 Mar 28;302(2):155-65.
2. Cha MY, et al. Int J Cancer. 2012 May 15;130(10):2445-54.
3. Kim HJ, et al. Anticancer Drugs. 2012 Mar;23(3):288-97.
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