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Ponesimod
CAS No. 854107-55-4
Ponesimod ( ACT-128800 )
Catalog No. M16202 CAS No. 854107-55-4
A potent, selective, orally active S1P1 receptor agonist with EC50 of 9.1 nM; shows weak activity on S1P3 (EC50=123 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 49 | In Stock |
|
| 5MG | 77 | In Stock |
|
| 10MG | 120 | In Stock |
|
| 25MG | 221 | In Stock |
|
| 50MG | 383 | In Stock |
|
| 100MG | 565 | In Stock |
|
| 500MG | 1215 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePonesimod
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, orally active S1P1 receptor agonist with EC50 of 9.1 nM; shows weak activity on S1P3 (EC50=123 nM).
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DescriptionA potent, selective, orally active S1P1 receptor agonist with EC50 of 9.1 nM; shows weak activity on S1P3 (EC50=123 nM); activates S1P1-mediated signal transduction with high potency (EC50 of 5.7 nM); causes maximal reduction of circulating lymphocytes at a dose of 3 mg/kg.Multiple Sclerosis Phase 3 Clinical
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SynonymsACT-128800
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PathwayGPCR/G Protein
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TargetLysophospholipid Receptor
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RecptorS1P1
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Research AreaInflammation/Immunology
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IndicationMultiple Sclerosis
Chemical Information
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CAS Number854107-55-4
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Formula Weight460.97
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Molecular FormulaC23H25ClN2O4S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C1N(C2=CC=CC=C2C)/C(S/C1=C\C3=CC=C(OC[C@H](O)CO)C(Cl)=C3)=N/CCC
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Chemical Name4-Thiazolidinone, 5-[[3-chloro-4-[(2R)-2,3-dihydroxypropoxy]phenyl]methylene]-3-(2-methylphenyl)-2-(propylimino)-, (2Z,5Z)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bolli MH, et al. J Med Chem. 2010 May 27;53(10):4198-211.
2. Piali L, et al. J Pharmacol Exp Ther. 2011 May;337(2):547-56.
3. Sobel K, et al. J Biol Chem. 2013 May 24;288(21):14839-51.
2. Piali L, et al. J Pharmacol Exp Ther. 2011 May;337(2):547-56.
3. Sobel K, et al. J Biol Chem. 2013 May 24;288(21):14839-51.
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