Pomstafib-1 ( Pomstafib 1 )

Catalog No. M12578 CAS No. 1688703-35-6

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Datasheet

HNMR

HPLC

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Product Name

Pomstafib-1
Note

Research use only, not for human use.
Brief Description

The cell-permeable, pivaloyloxymethylester of Stafib-1, which is a potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 44 nM.
Description

The cell-permeable, pivaloyloxymethylester of Stafib-1, which is a potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 44 nM, >50-fold selectivity over STAT5a; inhibits tyrosine phosphorylation of a STAT5b-GFP fusion protein with high selectivity over the corresponding STAT5a-GFP fusion protein in human leukemia cells; is a valuable tool for dissecting the functions of STAT5b and STAT5a in mammalian cells.
Synonyms

Pomstafib 1
Pathway

JAK/STAT Signaling
Target

STAT
Recptor

STAT
Research Area

——
Indication

——

CAS Number

1688703-35-6
Formula Weight

1059.01
Molecular Formula

C50H64N2O19P2
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

((((4-((2-((6-(phenylcarbamoyl)naphthalen-2-yl)oxy)acetamido)methyl)-1,2-phenylene)bis(oxy))bis(oxo-l5-phosphanetriyl))tetrakis(oxy))tetrakis(methylene) tetrakis(2,2-dimethylpropanoate)

1. Elumalai N, et al. Angew Chem Int Ed Engl. 2015 Apr 13;54(16):4758-63.
2. Elumalai N, et al. Bioorg Med Chem. 2017 Jul 15;25(14):3871-3882.

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