Platycodin D( —— )

Catalog No. M18847 CAS No. 58479-68-8

Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 12-O-tetradecanoyl phorbol 13-acetate (TPA).

Purity : >98% (HPLC)

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Biological Information

Product Name

Platycodin D
Note

Research use only, not for human use.
Brief Description

Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 12-O-tetradecanoyl phorbol 13-acetate (TPA).
Description

Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 12-O-tetradecanoyl phorbol 13-acetate (TPA). Platycodin D and D3 are useful as expectorant agents in the treatment of various airway diseases, they can increase mucin release from rat and hamster tracheal surface epithelial cell culture and also from intact rat trachea upon nebulization.
In Vitro

——
In Vivo

Animal Model:Genetically obese db/db mice Dosage:5 mg/kg Administration:Oral administration; 5 mg/kg, 5 times per week for 5 weeks Result:Significantly decreased body weight gain without affecting food intake of mice. Decreased the liver tissue weight and increased the weight of brown adipose tissue (BAT).
Synonyms

——
Pathway

Endocrinology/Hormones
Target

AChR
Recptor

PGE2
Research Area

Others-Field
Indication

——

Chemical Information

CAS Number

58479-68-8
Formula Weight

1225.34
Molecular Formula

C57H92O28
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (40.81 mM)
SMILES

C1C(CC[C@@]2([C@@H](C[C@@]3([C@@]4(CC[C@H]5C([C@H]([C@H](C[C@@]5(C4CC=C3[C@H]12)C)O)O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO)(CO)CO)C)C)O)C(=O)O[C@@H]1OC[C@@H]([C@@H]([C@H]1O[C@@H]1O[C@H]([C@@H]([C@H]([C@H]1O)O)O[C@@H]1OC[C@H]([C@@H]([C@H]1O)O[C@@H]1OC[C@@]([C@H]1O)(CO)O)O)C)O)O)(C)C
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Kwon OG,ET AL. The Effects of Platycodin D, a Saponin Purified from Platycodi Radix, on Collagen-Induced DBA/1J Mouse Rheumatoid Arthritis. Evid Based Complement Alternat Med. 2014;2014:954508.

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