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LY 334370
CAS No. 182563-08-2
LY 334370( —— )
Catalog No. M18144 CAS No. 182563-08-2
LY334370 is a selective 5-HT1F receptor agonist with a Ki of 1.6 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 29 | In Stock |
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| 10MG | 39 | In Stock |
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| 25MG | 88 | In Stock |
|
| 50MG | 128 | In Stock |
|
| 100MG | 187 | In Stock |
|
| 200MG | 259 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLY 334370
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NoteResearch use only, not for human use.
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Brief DescriptionLY334370 is a selective 5-HT1F receptor agonist with a Ki of 1.6 nM.
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DescriptionLY334370 is a selective 5-HT1F receptor agonist with a Ki of 1.6 nM
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In VitroLY334370 has no vasoconstrictor effects on human cerebral arteries in vitro until a dose of 10-5 M, at which it produces a contraction of 8.5±5.7%; however, this is not significant.
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In VivoFollowing intravenous administration of LY334370 at 3 mg/kg (n=3) or 10 mg/kg (n=6) electrical stimulation evokes an increase in dural blood vessel diameter of 135±6% and 106±11%, respectively, which is not significantly different from the respective control values. LY334370 has no effect on dural blood vessel diameter per se, since the actualdural blood vessel diameter is 43±4 arbitrary units before drug and 43±4 arbitrary units 15 min after injection of LY334370 (10 mg/kg).
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetAChR
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Recptor5-HT1F
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Research AreaNeurological Disease
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Indication——
Chemical Information
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CAS Number182563-08-2
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Formula Weight351.42
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Molecular FormulaC21H22FN3O
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Purity>98% (HPLC)
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SolubilityDMSO : ≥ 55.5 mg/mL; 157.93 mM
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SMILESO=C(NC1=CC2=C(NC=C2C3CCN(C)CC3)C=C1)C4=CC=C(F)C=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Shepheard S, et al. Possible antimigraine mechanisms of action of the 5HT1F receptor agonist LY334370. Cephalalgia. 1999 Dec;19(10):851-8.
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