Pivanex
CAS No. 122110-53-6
Pivanex ( AN-9; Pivalyloxymethyl butyrate )
Catalog No. M26790 CAS No. 122110-53-6
Pivanex is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein and enhances apoptosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 35 | In Stock |
|
10MG | 53 | In Stock |
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25MG | 110 | In Stock |
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50MG | 170 | In Stock |
|
100MG | 259 | In Stock |
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200MG | 385 | In Stock |
|
500MG | 617 | In Stock |
|
1G | Get Quote | In Stock |
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Biological Information
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Product NamePivanex
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NoteResearch use only, not for human use.
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Brief DescriptionPivanex is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein and enhances apoptosis.
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DescriptionPivanex is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein and enhances apoptosis.(In Vitro):In K562 cells, Pivanex (100-500 μM) exhibits significant anti-proliferation activity and enhances apoptosis and caspase activity. Pivanex (200 μM) induces enhancement in the G2-M phase, a moderate enhancement in the S phase, and a slight reduction in G0-G1 of the cell cycle.(In Vivo):Pivanex(200 mg/kg, b.i.d, daily) treatment marked delays in the end stage of disease as defined by the onset of body mass loss by 94.9%. Pivanex(200 mg/kg, b.i.d, daily) obviously improves the survival of SMN7 SMA mice by 84.6%.
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SynonymsAN-9; Pivalyloxymethyl butyrate
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PathwayApoptosis
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TargetApoptosis
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RecptorGSK-3α; GSK-3β
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Research Area——
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Indication——
Chemical Information
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CAS Number122110-53-6
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Formula Weight202.3
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Molecular FormulaC10H18O4
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Purity>98% (HPLC)
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Solubility——
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SMILESCCCC(=O)OCOC(=O)C(C)(C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Prabhakaran J, et al. Radiosynthesis and in Vivo Evaluation of [11C]A1070722, a High Affinity GSK-3 PET Tracer in Primate Brain. ACS Chem Neurosci. 2017 Aug 16;8(8):1697-1703.
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