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Pitolisant

CAS No. 362665-56-3

Pitolisant ( Tiprolisant;BF-2649;BF 2.649 )

Catalog No. M14244 CAS No. 362665-56-3

A potent and selective antagonist of H3 receptor with Ki/EC50 of 0.16/1.5 nM; no effect on H1, H2, H4 receptors (IC50>10 uM).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Pitolisant
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective antagonist of H3 receptor with Ki/EC50 of 0.16/1.5 nM; no effect on H1, H2, H4 receptors (IC50>10 uM).
  • Description
    A potent and selective antagonist of H3 receptor with Ki/EC50 of 0.16/1.5 nM; no effect on H1, H2, H4 receptors (IC50>10 uM); orally bioactive.Sleep Disorder Approved
  • Synonyms
    Tiprolisant;BF-2649;BF 2.649
  • Pathway
    GPCR/G Protein
  • Target
    Histamine Receptor
  • Recptor
    Histamine Receptor
  • Research Area
    Neurological Disease
  • Indication
    Sleep Disorder

Chemical Information

  • CAS Number
    362665-56-3
  • Formula Weight
    295.85
  • Molecular Formula
    C17H26ClNO
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    C1CCN(CC1)CCCOCCCC2=CC=C(C=C2)Cl
  • Chemical Name
    Piperidine, 1-[3-[3-(4-chlorophenyl)propoxy]propyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ligneau X, et al. J Pharmacol Exp Ther. 2007 Jan;320(1):365-75.
2. Dudek M, et al. Metab Brain Dis. 2016 Oct;31(5):1023-9.
3. Ligneau X, et al. Biochem Pharmacol. 2007 Apr 15;73(8):1215-24.
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