Pirarubicin ( Tepirubicin; Tetrahydropyranyl-Doxorubicin; THP-Adriamycin; THP-Doxorubicin )

Catalog No. M15775 CAS No. 72496-41-4

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Product Name

Pirarubicin
Note

Research use only, not for human use.
Brief Description

Pirarubicin is an anthracycline antibiotic, and also a DNA/RNA synthesis inhibitor by intercalating into Dna and interacts with topoisomerase II, used as an antineoplastic agent.
Description

Pirarubicin is an anthracycline antibiotic, and also a DNA/RNA synthesis inhibitor by intercalating into Dna and interacts with topoisomerase II, used as an antineoplastic agent.
Synonyms

Tepirubicin; Tetrahydropyranyl-Doxorubicin; THP-Adriamycin; THP-Doxorubicin
Pathway

Cell Cycle/DNA Damage
Target

Topoisomerase
Recptor

Topo II
Research Area

Cancer
Indication

——

CAS Number

72496-41-4
Formula Weight

627.64
Molecular Formula

C32H37NO12
Purity

>98%(HPLC)
Solubility

DMSO:7 mg/mL (11.15 mM); Ethanol:<1 mg/mL (<1 mM); Water:<1 mg/mL (<1 mM)
SMILES

O=C1C2=C(O)C(C[C@](C(CO)=O)(O)C[C@@H]3O[C@H]4C[C@H](N)[C@H](O[C@H]5CCCCO5)[C@H](C)O4)=C3C(O)=C2C(C6=C1C=CC=C6OC)=O
Chemical Name

(8S,10S)-10-(((2R,4S,5S,6S)-4-amino-6-methyl-5-(((S)-tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione

1. Sugiyama T, et al. Jpn J Cancer Res, 1999, 90(7), 775-780.

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