Pimecrolimus ( Elidel; SDZ-ASM 981 )

Catalog No. M11529 CAS No. 137071-32-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Pimecrolimus
Note

Research use only, not for human use.
Brief Description

Pimecrolimus, like all ascomycins, is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12.
Description

Pimecrolimus, like all ascomycins, is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12.
Synonyms

Elidel; SDZ-ASM 981
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Inflammation/Immunology
Indication

——

CAS Number

137071-32-0
Formula Weight

810.45
Molecular Formula

C43H68ClNO11
Purity

>98%(HPLC)
Solubility

Ethanol: 100 mg/mL (123.38 mM); DMSO: 100 mg/mL (123.38 mM)
SMILES

O=C(C(N1CCCC[C@@]1([H])C(O[C@H](/C(C)=C/[C@H]2C[C@@H](OC)[C@@H](Cl)CC2)[C@H](C)[C@@H](O)C3)=O)=O)[C@@](O4)(O)[C@H](C)C[C@H](OC)[C@@]4([H])[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@@H](CC)C3=O
Chemical Name

(1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-12-[(1E)-2{(1R,3R,4S)-4-chloro-3-methoxycyclohexyl}-1-methylvinyl]-17-ethyl-1,14-dihydroxy-23,25 dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-aza-tricyclo[22.3.1.0 4,9]octacos-18-ene2,3,10,16-tetraone.

1.Nghiem P, et al. Am Acad Dermatol, 2002, 46(2), 228-24

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