Picropodophyllin
CAS No. 477-47-4
Picropodophyllin ( AXL1717; AXL-1717; AXL 1717; PPP; picropodophyllin )
Catalog No. M17519 CAS No. 477-47-4
Picropodophyllin (PPP) is a specific IGF-1R inhibitor (IC50: 1 nM). Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 52 | In Stock |
|
10MG | 72 | In Stock |
|
25MG | 160 | In Stock |
|
50MG | 300 | In Stock |
|
100MG | 507 | In Stock |
|
500MG | 1062 | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
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Product NamePicropodophyllin
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NoteResearch use only, not for human use.
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Brief DescriptionPicropodophyllin (PPP) is a specific IGF-1R inhibitor (IC50: 1 nM). Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors.
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DescriptionPicropodophyllin, also known as Picropodophyllotoxin, AXL1717 or PPP, is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential antineoplastic activity. Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with activities of other growth factor receptors, such as receptors for insulin, epidermal growth factor, platelet-derived growth factor, fibroblast growth factor and mast/stem cell growth factor (KIT). This agent shows potent activity in the suppression o f tumor cell proliferation and the induction of tumor cell apoptosis.
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SynonymsAXL1717; AXL-1717; AXL 1717; PPP; picropodophyllin
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PathwayOthers
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TargetOther Targets
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RecptorIGF-1R
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number477-47-4
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Formula Weight414.41
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Molecular FormulaC22H22O8
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Purity98%
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SolubilityDMSO : 50 mg/mL. 120.65 mM;
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SMILESCOc1cc(cc(c1OC)OC)[C@H]1[C@H]2[C@H](COC2=O)[C@H](c2cc3c(cc12)OCO3)O
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Chemical Name(5R,5aS,8aR,9R)-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lemaire M, Fristedt C, Agarwal P, et al. Clin Cancer Res. 2012 Apr 15;18(8):2230-9.
molnova catalog
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