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PIN1 inhibitor API-1
CAS No. 680622-70-2
PIN1 inhibitor API-1( —— )
Catalog No. M24694 CAS No. 680622-70-2
PIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM). PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from the nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 136 | In Stock |
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| 5MG | 123 | In Stock |
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| 10MG | 235 | In Stock |
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| 25MG | 345 | In Stock |
|
| 50MG | 500 | In Stock |
|
| 100MG | 631 | In Stock |
|
| 200MG | 879 | In Stock |
|
| 500MG | 1283 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePIN1 inhibitor API-1
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NoteResearch use only, not for human use.
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Brief DescriptionPIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM). PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from the nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development.
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DescriptionPIN1 inhibitor API-1 is a specific Pin1 inhibitor (IC50: 72.3 nM). PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from the nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase domain and effectively inhibits Pin1 cis-trans isomerizing activity.
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In VitroPIN1 inhibitor API-1 obviously inhibits SK-Hep-1, SNU-423, and Hep3B cell proliferation with low IC50 values (IC50=0.683-4.16 μM).
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In VivoPIN1 inhibitor API-1 suppresses tumor growth in mice by up-regulating mature miRNA biogenesis.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPin1
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Research Area——
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Indication——
Chemical Information
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CAS Number680622-70-2
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Formula Weight366.3
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Molecular FormulaC15H13F3N6O2
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Purity>98% (HPLC)
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SolubilityDMSO:250 mg/mL (682.50 mM; Need ultrasonic)
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SMILESC1=CC(=CC=C1CNC(=O)C(F)(F)F)COC2=NC(=NC3=C2NC=N3)N
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Pu W, et al. Targeting Pin1 by inhibitor API-1 regulates microRNA biogenesis and suppresses hepatocellularcarcinoma development. Hepatology. 2018 Aug;68(2):547-560.
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