Phenylbiguanide

CAS No. 102-02-3

Phenylbiguanide( N-Phenylbiguanide | PBG | 1-Phenylbiguanide )

Catalog No. M20627 CAS No. 102-02-3

Phenylbiguanide is a 5-HT3 receptor selective agonist(EC50 : 3.0±0.1 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Phenylbiguanide
  • Note
    Research use only, not for human use.
  • Brief Description
    Phenylbiguanide is a 5-HT3 receptor selective agonist(EC50 : 3.0±0.1 μM).
  • Description
    Phenylbiguanide is a 5-HT3 receptor selective agonist(EC50 : 3.0±0.1 μM).
  • In Vitro
    Phenylbiguanide (1-Phenylbiguanide) is a 5-HT3 receptor selective agonist with pEC50s of 5.57, 4.07, and 4.47 for r5-HT3A(b), h5-HT3A, m5-HT3A(b) , respectively. The effect of Phenylbiguanide (1-Phenylbiguanide hydrochloride) in promoting the growth of the HT29 cell line is investigated. Phenylbiguanide causes a dose dependent proliferation of HT29 cells after 48 hours incubation. The maximum proliferation is at a 5HT concentration of 12.5 μM (P≤0.01). Phenylbiguanide significantly stimulates the growth of cells at concentrations of 3.125 μM (P≤0.05) and 6.25 μM (P≤0.01).
  • In Vivo
    In anaesthetised mice, Phenylbiguanide (PBG), a drug that is known to stimulate cardiopulmonary afferent C-fibres,is injected into the right atrium of the heart and mapped c-Fos expression within specific regions of the central nervous system. Intraatrial injection of PBG produces a reflex cardiorespiratory response including a pronounced bradycardia and a respiratory depression.
  • Synonyms
    N-Phenylbiguanide | PBG | 1-Phenylbiguanide
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    102-02-3
  • Formula Weight
    177.21
  • Molecular Formula
    C8H11N5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:150 mg/mL (846.45 mM)
  • SMILES
    NC(=N)NC(=N)Nc1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.de Vries A Paton JF Lightman SLet al.Characterisation of c-Fos expression in the central nervous system of mice following right atrial injections of the 5-HT3 receptor agonist phenylbiguanide[J].Auton Neurosci. 2005 Dec 30;123(1-2):62-75.
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