
Phenylbiguanide
CAS No. 102-02-3
Phenylbiguanide( N-Phenylbiguanide | PBG | 1-Phenylbiguanide )
Catalog No. M20627 CAS No. 102-02-3
Phenylbiguanide is a 5-HT3 receptor selective agonist(EC50 : 3.0±0.1 μM).
Purity : >98% (HPLC)






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Biological Information
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Product NamePhenylbiguanide
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NoteResearch use only, not for human use.
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Brief DescriptionPhenylbiguanide is a 5-HT3 receptor selective agonist(EC50 : 3.0±0.1 μM).
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DescriptionPhenylbiguanide is a 5-HT3 receptor selective agonist(EC50 : 3.0±0.1 μM).
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In VitroPhenylbiguanide (1-Phenylbiguanide) is a 5-HT3 receptor selective agonist with pEC50s of 5.57, 4.07, and 4.47 for r5-HT3A(b), h5-HT3A, m5-HT3A(b) , respectively. The effect of Phenylbiguanide (1-Phenylbiguanide hydrochloride) in promoting the growth of the HT29 cell line is investigated. Phenylbiguanide causes a dose dependent proliferation of HT29 cells after 48 hours incubation. The maximum proliferation is at a 5HT concentration of 12.5 μM (P≤0.01). Phenylbiguanide significantly stimulates the growth of cells at concentrations of 3.125 μM (P≤0.05) and 6.25 μM (P≤0.01).
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In VivoIn anaesthetised mice, Phenylbiguanide (PBG), a drug that is known to stimulate cardiopulmonary afferent C-fibres,is injected into the right atrium of the heart and mapped c-Fos expression within specific regions of the central nervous system. Intraatrial injection of PBG produces a reflex cardiorespiratory response including a pronounced bradycardia and a respiratory depression.
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SynonymsN-Phenylbiguanide | PBG | 1-Phenylbiguanide
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT3
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Research Area——
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Indication——
Chemical Information
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CAS Number102-02-3
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Formula Weight177.21
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Molecular FormulaC8H11N5
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Purity>98% (HPLC)
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SolubilityDMSO:150 mg/mL (846.45 mM)
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SMILESNC(=N)NC(=N)Nc1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.de Vries A Paton JF Lightman SLet al.Characterisation of c-Fos expression in the central nervous system of mice following right atrial injections of the 5-HT3 receptor agonist phenylbiguanide[J].Auton Neurosci. 2005 Dec 30;123(1-2):62-75.
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