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MK-212

CAS No. 61655-58-1

MK-212( MK 212 | MK212 )

Catalog No. M15329 CAS No. 61655-58-1

A potent, selective 5-HT2C receptor agonist with IC50 of 20 nM in HEK293 cells-exppressed 5-HT2C, shows weakly activity for 5-HT2A.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MK-212
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective 5-HT2C receptor agonist with IC50 of 20 nM in HEK293 cells-exppressed 5-HT2C, shows weakly activity for 5-HT2A.
  • Description
    A potent, selective 5-HT2C receptor agonist with IC50 of 20 nM in HEK293 cells-exppressed 5-HT2C, shows weakly activity for 5-HT2A; stimulates phosphoinositide hydrolysis in cerebral cortex, antagonizes the analgesia induced by either morphine or THIP in vivo.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    MK 212 | MK212
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    61655-58-1
  • Formula Weight
    235.12
  • Molecular Formula
    C8H11ClN4.HCl
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 10 mg/mL (42.53 mM)
  • SMILES
    ClC1=CN=CC(N2CCNCC2)=N1.[H]Cl
  • Chemical Name
    6-Chloro-2-(1-piperazinyl)pyrazine hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Conn PJ, et al. J Pharmacol Exp Ther. 1987 Aug;242(2):552-7. 2. Hemrick-Luecke SK, et al. Eur J Pharmacol. 1996 Sep 12;311(2-3):207-11. 3. Jensen AA, et al. J Med Chem. 2013 Feb 14;56(3):1211-27. 4. Murray TF, et al. Eur J Pharmacol. 1983 Jun 3;90(2-3):179-84.
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