Periplocin( —— )

Catalog No. M17940 CAS No. 13137-64-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Periplocin
Note

Research use only, not for human use.
Brief Description

Periplocin has anti-cancer effects on lung cancer cells, induces apoptosis and inhibits growth of cancer cells by the beta-catenin/Tcf signaling pathway.
Description

Periplocin has anti-cancer effects on lung cancer cells, induces apoptosis and inhibits growth of cancer cells by the beta-catenin/Tcf signaling pathway. Periplocin is used for treatment of rheumatoid arthritis, reinforcement of bones and tendons, palpitations or shortness of breath and lower extremity edema in traditional medicine.
In Vitro

Cell Viability Assay Cell Line:L929 cells Concentration:5 μM, 10 μM, 20 μM Incubation Time:48 hours Result:Showed increased proliferation up to 131% at 20 μM.Western Blot Analysis Cell Line:L929 cells Concentration:5 μM, 10 μM, 20 μM Incubation Time:30 minutes, 60 minutes, 120 minutes Result:Increased phosphorylation of Src, ERK, PI3K and Akt at active sites in a dosedependent and time-dependent manner.
In Vivo

Animal Model:Female SCID mice (6-8 weeks old) injected with Huh-7 cells Dosage:5 mg/kg, 20 mg/kg Administration:Intraperitoneal injection; daily; for 14 days Result:Repressed the growth of hepatocellular carcinoma (HCC) in xenograft tumor model in mice.
Synonyms

——
Pathway

Cytoskeleton/Cell Adhesion Molecules
Target

HSP
Recptor

Others
Research Area

——
Indication

——

CAS Number

13137-64-9
Formula Weight

696.83
Molecular Formula

C36H56O13
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (143.51 mM)
SMILES

CC1C(C(CC(O1)OC2CCC3(C4CCC5(C(CCC5(C4CCC3(C2)O)O)C6=CC(=O)OC6)C)C)OC)OC7C(C(C(C(O7)CO)O)O)O
Chemical Name

——