Parbendazole

Research use only, not for human use.

Parbendazole is a potent inhibitor of microtubule assembly(EC50 : 8.79?nM).Parbendazole is a carbamate ester-amine. It finds applications in control or treatment of nematode infestations.

Parbendazole is a potent inhibitor of microtubule assembly(EC50 : 8.79?nM).Parbendazole is a carbamate ester-amine. It finds applications in control or treatment of nematode infestations.

Parbendazole is a tubulin destabilizer, with an EC50 of 530?nM, and can induce DNA damage. Parbendazole (2-10 μM) inhibits the assembly of microtubules dose-dependently, with an IC50 of 3 μM. Parbendazole (2-20 μM)-treated cells show an complete absence of microtubules in Vero cells. Parbendazole (up to 10 μM) inhibits the growth of CLd-AXE myxamoebae. Parbendazole (2-5 μM) potently inhibits tubulin purified from the wild-type myxamoebae.

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SKF 29044

Cytoskeleton/Cell Adhesion Molecules

Microtubule/Tubulin

microtubule

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14255-87-9

247.29

C13H17N3O2

>98% (HPLC)

DMSO:4 mg/mL (16.18 mM)

CCCCc1ccc2nc(NC(=O)OC)[nH]c2c1

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(-20℃)

With Ice Pack

≥ 2 years