PZ-2891( —— )

Catalog No. M20770 CAS No. 2170608-82-7

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Datasheet

HNMR

HPLC

MSDS

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Product Name

PZ-2891
Note

Research use only, not for human use.
Brief Description

PZ-2891 is an orally bioavailable brain penetrant pantothenate kinase (PANK) modulator(hPANK3IC50:1.3 nM).
Description

PZ-2891 is an orally bioavailable brain penetrant pantothenate kinase (PANK) modulator(hPANK3IC50:1.3 nM).
In Vitro

PZ-2891 inhibits mouse pantothenate kinases PANK1β, PANK2, and PANK3 with IC50s of48.7±5.1 nM, 1.0±0.1 nM, and 1.9±0.2 nM, respectively.
In Vivo

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Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

pantothenate kinase (PANK)
Research Area

——
Indication

——

CAS Number

2170608-82-7
Formula Weight

349.43
Molecular Formula

C20H23N5O
Purity

>98% (HPLC)
Solubility

DMSO:75 mg/mL (214.64 mM)
SMILES

CC(C)c1ccc(CC(=O)N2CCN(c3ccc(C#N)nn3)CC2)cc1
Chemical Name

6-(4-(2-(4-isopropylphenyl)acetyl)piperazin-1-yl)pyridazine-3-carbonitrile

1.Lalit Kumar Sharma et al. A therapeutic approach to pantothenate kinase associated neurodegeneration.[J]. Nature communications 2018.

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