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L-655708
CAS No. 130477-52-0
L-655708( —— )
Catalog No. M37943 CAS No. 130477-52-0
L-655708 is a selective and highly potent GABAA receptor reverse agonist with a Ki value of 0.45 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 73 | In Stock |
|
| 10MG | 121 | In Stock |
|
| 25MG | 242 | In Stock |
|
| 50MG | 476 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameL-655708
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NoteResearch use only, not for human use.
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Brief DescriptionL-655708 is a selective and highly potent GABAA receptor reverse agonist with a Ki value of 0.45 nM.
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DescriptionL-655708 is a potent α5 subunit-selective GABAA receptor inverse agonist (Ki=0.45 nM).
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In VitroL655708 is a potent, selective inverse agonist for the benzodiazepine site of GABAA receptors containing the α5 subunit (Ki = 0.45 nM). Displays 50-100-fold selectivity over GABAA receptors containing α1, α2, α3 orα6 subunits in combination with β3 and γ2. Enhances LTP in a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity.
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In VivoL-655708 at 0.7 mg/kg, administered intraperitoneally, would result in 60-70% occupancy of α5 GABAA receptors with limited binding to α1, α2, and α3 subunit-containing GABAA receptors and no significant off-target behavioral effects, such as sedation and motor impairment.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorGABA Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number130477-52-0
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Formula Weight341.36
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Molecular FormulaC18H19N3O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 10 mg/mL (29.29 mM; Ultrasonic (<60°C)
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SMILES[H][C@@]12CCCN1C(=O)c1cc(OC)ccc1-n1cnc(C(=O)OCC)c21
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Saab BJ, et al. Short-term memory impairment after isoflurane in mice is prevented by the α5 γ-aminobutyric acid type A receptorinverse agonist L-655708. Anesthesiology. 2010 Nov;113(5):1061-1071.?
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