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PU-02

CAS No. 313984-77-9

PU-02( 6-[(1-Naphthalenylmethyl)thio]-9H-purine )

Catalog No. M21984 CAS No. 313984-77-9

PU-02 is a potent and selective antagonist of 5-HT3 receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PU-02
  • Note
    Research use only, not for human use.
  • Brief Description
    PU-02 is a potent and selective antagonist of 5-HT3 receptor.
  • Description
    PU-02 is a potent and selective antagonist of 5-HT3 receptor.
  • In Vitro
    PU02 (NMMP) (0-200 μM) leads to a steady decrease in cell viability of HepG2 cells (IC50=48.585 μM). PU02 (NMMP) shows less toxicity on L02 cells than did 6-MP after 48 h of treatment.PU02 (NMMP) at 6.25 or 25 μM exhibits inhibitory effects on the viability of the tested cell lines, including SMMC-7721, MDA-MB-231, RKO and HCT-8 cells.PU02 (NMMP) induces cell cycle arrest at the G2/M phase. PU02 (NMMP) downregulats the expression of cyclin B1/D1 and CDK4 in a time-dependent manner in HepG2 cells,but the expression of cyclin E is not affected.PU02 (NMMP)-treated cells exhibits a significant increase in caspase-3 cleavage, suggesting enhanced apoptotic activity. Apoptosis AnalysisCell Line:HepG2 cells.Concentration:6.26, 12.5, 25, 50 μM.Incubation Time:6, 12, 24, 36 h.Result:Induced mitochondria-dependent apoptosis.
  • In Vivo
    ——
  • Synonyms
    6-[(1-Naphthalenylmethyl)thio]-9H-purine
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT3
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    313984-77-9
  • Formula Weight
    292.36
  • Molecular Formula
    C16H12N4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (855.11 mM)
  • SMILES
    C(Sc1ncnc2nc[nH]c12)c1cccc2ccccc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Trattnig S M , Harpsoe K , Thygesen S B , et al. Discovery of a Novel Allosteric Modulator of 5-HT3 Receptors: INHIBITION AND POTENTIATION OF CYS-LOOP RECEPTOR SIGNALING THROUGH A CONSERVED TRANSMEMBRANE INTERSUBUNIT SITE[J]. Journal of Biological Chemistry, 2012, 287(30):25241-25254.
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