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PTUPB

CAS No. 1287761-01-6

PTUPB( —— )

Catalog No. M11173 CAS No. 1287761-01-6

PTUPB is a novel dual acting COX-2/sEH inhibitor with IC50 of 1.26 uM/0.9 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    PTUPB
  • Note
    Research use only, not for human use.
  • Brief Description
    PTUPB is a novel dual acting COX-2/sEH inhibitor with IC50 of 1.26 uM/0.9 nM.
  • Description
    PTUPB is a novel dual acting COX-2/sEH inhibitor with IC50 of 1.26 uM/0.9 nM,does not inhibits COX-1 (IC50>100 uM); reduces kidney injury parameters, decreases inflammatory and oxidative stress markers in ZDF rats; exhibits more effective than the same dose of either COX-2 inhibitor (celecoxib) or sEH inhibitor (t-AUCB) alone, shows in vivo antiallodynic activity in vivo; also suppresses glioblastoma growth by targeting EGFR and hyaluronan mediated motility receptor, potentiates the antitumor efficacy of cisplatin.
  • In Vitro
    Cell Viability Assay Cell Line:Multiple cancer cell lines: PC-3 cells, Met-1, H-1, A375, and transformed endothelial cell line (bEnd.3)Concentration:10 μM, 15 μM, and 20 μM Incubation Time:72 hours Result:Inhibited HUVEC proliferation after 3 days.Cell Cycle Analysis Cell Line:HUVECs Concentration:10 μM, 15 μM, and 20 μM Incubation Time:72 hours Result:Induced cell cycle arrest at the G0/1 phase.
  • In Vivo
    Animal Model:C57BL/6 mice with?LLC cells Dosage:30 mg/kg; 4 weeks Administration:Subcutaneous injection via Alzet osmotic minipumps; once daily; 4 weeks Result:Inhibited LLC tumor growth and metastasis.Animal Model:High-fat diet (HFD)-induced obeseadult male C57BL/6 mice Dosage:5 mg/kg; 12 weeks Administration:Subcutaneous injection; once daily; 12 weeks Result:Arrested fibrotic progression and ameliorated high-fat diet-induced non-alcoholic fatty liver disease.
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    COX
  • Recptor
    COX
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1287761-01-6
  • Formula Weight
    543.565
  • Molecular Formula
    C26H24F3N5O3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (183.97 mM)
  • SMILES
    ——
  • Chemical Name
    4-(5-phenyl-3-{3-[3-(4-trifluoromethylphenyl)-ureido]-propyl}-pyrazol-1-yl)-benzenesulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hye Khan MA, et al. Prostaglandins Other Lipid Mediat. 2016 Sep;125:40-7. 2. Li J, et al. Oncotarget. 2017 Sep 15;8(50):87353-87363. 3. Wang F, et al. Mol Cancer Ther. 2018 Feb;17(2):474-483. 4. Hwang SH, et al. J Med Chem. 2011 Apr 28;54(8):3037-50.
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