Cart
sales@molnova.com
PTUPB
CAS No. 1287761-01-6
PTUPB ( —— )
Catalog No. M11173 CAS No. 1287761-01-6
PTUPB is a novel dual acting COX-2/sEH inhibitor with IC50 of 1.26 uM/0.9 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 260 | Get Quote |
|
| 10MG | 439 | Get Quote |
|
| 25MG | 718 | Get Quote |
|
| 50MG | 981 | Get Quote |
|
| 100MG | 1332 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NamePTUPB
-
NoteResearch use only, not for human use.
-
Brief DescriptionPTUPB is a novel dual acting COX-2/sEH inhibitor with IC50 of 1.26 uM/0.9 nM.
-
DescriptionPTUPB is a novel dual acting COX-2/sEH inhibitor with IC50 of 1.26 uM/0.9 nM,does not inhibits COX-1 (IC50>100 uM); reduces kidney injury parameters, decreases inflammatory and oxidative stress markers in ZDF rats; exhibits more effective than the same dose of either COX-2 inhibitor (celecoxib) or sEH inhibitor (t-AUCB) alone, shows in vivo antiallodynic activity in vivo; also suppresses glioblastoma growth by targeting EGFR and hyaluronan mediated motility receptor, potentiates the antitumor efficacy of cisplatin.
-
Synonyms——
-
PathwayChromatin/Epigenetic
-
TargetCOX
-
RecptorCOX
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1287761-01-6
-
Formula Weight543.57
-
Molecular FormulaC26H24F3N5O3S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES——
-
Chemical Name4-(5-phenyl-3-{3-[3-(4-trifluoromethylphenyl)-ureido]-propyl}-pyrazol-1-yl)-benzenesulfonamide
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Hye Khan MA, et al. Prostaglandins Other Lipid Mediat. 2016 Sep;125:40-7.
2. Li J, et al. Oncotarget. 2017 Sep 15;8(50):87353-87363.
3. Wang F, et al. Mol Cancer Ther. 2018 Feb;17(2):474-483.
4. Hwang SH, et al. J Med Chem. 2011 Apr 28;54(8):3037-50.
2. Li J, et al. Oncotarget. 2017 Sep 15;8(50):87353-87363.
3. Wang F, et al. Mol Cancer Ther. 2018 Feb;17(2):474-483.
4. Hwang SH, et al. J Med Chem. 2011 Apr 28;54(8):3037-50.
molnova catalog
related products
-
Acetylsalicylic acid
Aspirin (Acetylsalicylic acid) is a potent and selective inhibitor of cyclooxygenase (COX) with a broad range of pharmacological activities including anti-inflammation and pain relief.
-
(S)-Flurbiprofen
Esflurbiprofen is an inhibitor of COX-1 and COX-2.
-
Diethylcarbamazine c...
Diethylcarbamazine citrate is an inhibitor of arachidonic acid metabolism in filarial microfilaria; is highly specific for several parasites and does not contain any toxic metallic elements.
