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PTUPB
CAS No. 1287761-01-6
PTUPB ( —— )
Catalog No. M11173 CAS No. 1287761-01-6
PTUPB is a novel dual acting COX-2/sEH inhibitor with IC50 of 1.26 uM/0.9 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 260 | Get Quote |
|
| 10MG | 439 | Get Quote |
|
| 25MG | 718 | Get Quote |
|
| 50MG | 981 | Get Quote |
|
| 100MG | 1332 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NamePTUPB
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NoteResearch use only, not for human use.
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Brief DescriptionPTUPB is a novel dual acting COX-2/sEH inhibitor with IC50 of 1.26 uM/0.9 nM.
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DescriptionPTUPB is a novel dual acting COX-2/sEH inhibitor with IC50 of 1.26 uM/0.9 nM,does not inhibits COX-1 (IC50>100 uM); reduces kidney injury parameters, decreases inflammatory and oxidative stress markers in ZDF rats; exhibits more effective than the same dose of either COX-2 inhibitor (celecoxib) or sEH inhibitor (t-AUCB) alone, shows in vivo antiallodynic activity in vivo; also suppresses glioblastoma growth by targeting EGFR and hyaluronan mediated motility receptor, potentiates the antitumor efficacy of cisplatin.
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetCOX
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RecptorCOX
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Research Area——
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Indication——
Chemical Information
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CAS Number1287761-01-6
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Formula Weight543.57
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Molecular FormulaC26H24F3N5O3S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name4-(5-phenyl-3-{3-[3-(4-trifluoromethylphenyl)-ureido]-propyl}-pyrazol-1-yl)-benzenesulfonamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hye Khan MA, et al. Prostaglandins Other Lipid Mediat. 2016 Sep;125:40-7.
2. Li J, et al. Oncotarget. 2017 Sep 15;8(50):87353-87363.
3. Wang F, et al. Mol Cancer Ther. 2018 Feb;17(2):474-483.
4. Hwang SH, et al. J Med Chem. 2011 Apr 28;54(8):3037-50.
2. Li J, et al. Oncotarget. 2017 Sep 15;8(50):87353-87363.
3. Wang F, et al. Mol Cancer Ther. 2018 Feb;17(2):474-483.
4. Hwang SH, et al. J Med Chem. 2011 Apr 28;54(8):3037-50.
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