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Tolmetin
CAS No. 26171-23-3
Tolmetin( —— )
Catalog No. M13798 CAS No. 26171-23-3
Tolmetin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of tolmetin is as a Cyclooxygenase Inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 28 | In Stock |
|
| 50MG | 31 | In Stock |
|
| 100MG | 45 | In Stock |
|
| 200MG | 63 | In Stock |
|
| 500MG | 109 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTolmetin
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NoteResearch use only, not for human use.
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Brief DescriptionTolmetin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of tolmetin is as a Cyclooxygenase Inhibitor.
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DescriptionTolmetin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of tolmetin is as a Cyclooxygenase Inhibitor. The chemical classification of tolmetin is Nonsteroidal Anti-inflammatory Compounds.(In Vitro):Tolmetin (0.25 mM) does not attenuate lipid peroxidation in rat brain homogenate. Tolmetin (0.25, 0.5, 0.75, 1 mM) shows radical scavenging properties but without superoxide anion generation in rat brain homogenat.Tolmetin (0.001-100 μM) shows anticancer activity againts HT-29 colon cancer cell line in a dose-dependent manner.Tolmetin (0-100 μM) shows no effect on osteoblast growth.(In Vivo):Tolmetin (30,100 mg/kg; gavage; single dose or twice daily for 3 and 14 days) shows maximal ulcerogenic effect 4 h after the single dose, while potently decreases after 3 and 14 days of repeated administration in male Wistar rats weighing 180-200 g. Tolmetin causes gastric lesions in 100 mg/kg.Tolmetin (5 mg/kg twice a day for 5 days) pre-treatment considerably attenuates quinolinic acid (QA)-induced neurotoxicity.
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In VitroTolmetin (0.25 mM) does not attenuate lipid peroxidation in rat brain homogenate. Tolmetin (0.25, 0.5, 0.75, 1 mM) shows radical scavenging properties but without superoxide anion generation in rat brain homogenat. Tolmetin (0.001-100 μM) shows anticancer activity againts HT-29 colon cancer cell line in a dose-dependent manner.
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In VivoTolmetin (30,100 mg/kg; gavage; single dose or twice daily for 3 and 14 days) shows maximal ulcerogenic effect 4 h after the single dose, while potently decreases after 3 and 14 days of repeated administration in male Wistar rats weighing 180-200 g. Tolmetin causes gastric lesions in 100 mg/kg. Tolmetin (5 mg/kg twice a day for 5 days) pre-treatment considerably attenuates quinolinic acid (QA)-induced neurotoxicity.
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetCOX
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RecptorCOX-1| COX-2
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Research Area——
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Indication——
Chemical Information
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CAS Number26171-23-3
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Formula Weight257.28
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Molecular FormulaC15H15NO3
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Purity>98% (HPLC)
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SolubilityDMSO: 10 mM
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SMILESCN1C(CC(O)=O)=CC=C1C(=O)C1=CC=C(C)C=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Burdan F, et al. Pharmacol Res. 2004 Nov;50(5):533-43.
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