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PTC-209
CAS No. 315704-66-6
PTC-209( —— )
Catalog No. M14027 CAS No. 315704-66-6
PTC-209 is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM in HEK293T cell line, and results in irreversible reduction of Y-initiating cells (CICs).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 42 | In Stock |
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| 5MG | 61 | In Stock |
|
| 10MG | 105 | In Stock |
|
| 50MG | 397 | In Stock |
|
| 100MG | 406 | In Stock |
|
| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePTC-209
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NoteResearch use only, not for human use.
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Brief DescriptionPTC-209 is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM in HEK293T cell line, and results in irreversible reduction of Y-initiating cells (CICs).
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DescriptionPTC-209 is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM in HEK293T cell line, and results in irreversible reduction of Y-initiating cells (CICs).
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In VitroCell Viability Assay Cell Line:Lung (LNM35, A549 cells), breast (MDA-MB-231 and T47D cells), and colon (HT-29, HCT-116, and HCT8/S11 cells)Concentration:0.01-10 μM Incubation Time:24, 48, and 72 hour Result:Induced a concentration- and time-dependent decrease in the cellular viability of all cell lines tested.
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In VivoAnimal Model:Nude mice (male, aged 8-10 weeks, HCT1116 cell-derived tumor)Dosage:60 mg/kg body weight Administration:Subcutaneously; once a day for 11 days Result:Significantly reduced tumor volume
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Synonyms——
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PathwayOthers
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TargetBMI-1
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RecptorBMI-1
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number315704-66-6
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Formula Weight495.19
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Molecular FormulaC17H13Br2N5OS
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Purity>98% (HPLC)
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SolubilityDMSO: 99 mg/mL (199.92 mM)
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SMILESCOC1=CC(Br)=C(NC2=NC(=CS2)C2=C(C)N=C3N=CC=CN23)C(Br)=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kreso A, et al. nat Med. 2014, 20(1), 29-36.
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PTC-209
PTC-209 is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM in HEK293T cell line, and results in irreversible reduction of Y-initiating cells (CICs).
