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PSB-12062
CAS No. 55476-47-6
PSB-12062( N-(p-Methylphenylsulfonyl)phenoxazine )
Catalog No. M22429 CAS No. 55476-47-6
PSB-12062 is a potent and selective antagonist of P2X4(IC50 of 1.38 μM for human P2X4). PSB-12062 is ?a selective P2X4 antagonist that was equally potent in all three species (IC(50): 0.928-1.76 μM).?The compounds showed an allosteric mechanism of action.?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 42 | In Stock |
|
| 10MG | 65 | In Stock |
|
| 25MG | 146 | In Stock |
|
| 50MG | 249 | In Stock |
|
| 100MG | 438 | In Stock |
|
| 500MG | 954 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePSB-12062
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NoteResearch use only, not for human use.
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Brief DescriptionPSB-12062 is a potent and selective antagonist of P2X4(IC50 of 1.38 μM for human P2X4). PSB-12062 is ?a selective P2X4 antagonist that was equally potent in all three species (IC(50): 0.928-1.76 μM).?The compounds showed an allosteric mechanism of action.?
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DescriptionPSB-12062 is a potent and selective antagonist of P2X4(IC50 of 1.38 μM for human P2X4). PSB-12062 is ?a selective P2X4 antagonist that was equally potent in all three species (IC(50): 0.928-1.76 μM).?The compounds showed an allosteric mechanism of action.?
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In VitroPSB-12062 shows similar potency in human, rat, and mouse species. PSB-12062 shows to be allosteric in nature with a 35-fold selectivity toward P2X4 versus P2X1, P2X2, P2X3, and P2X7. However, PSB-12062 is unable to completely block ATP-induced P2X4-mediated calcium influx even when used at high concentrations (>30 μM).
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In Vivo——
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SynonymsN-(p-Methylphenylsulfonyl)phenoxazine
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PathwayNeuroscience
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TargetP2 Receptor
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RecptorP2X4
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Research Area——
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Indication——
Chemical Information
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CAS Number55476-47-6
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Formula Weight337.39
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Molecular FormulaC19H15NO3S
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Purity>98% (HPLC)
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SolubilityDMSO:24 mg/mL (71.13mM; Need ultrasonic)
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SMILESCc1ccc(cc1)S(=O)(=O)N1c2ccccc2Oc2ccccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hernandez-Olmos V, et al. N-substituted phenoxazine and acridone derivatives: structure-activity relationships of potent P2X4 receptor antagonists. J Med Chem. 2012 Nov 26;55(22):9576-88.
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