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PRI-724
CAS No. 847591-62-2
PRI-724( PRI 724 | PRI724 )
Catalog No. M16152 CAS No. 847591-62-2
PRI-724 (PRI724)?is a potent, specific, second generation CBP/beta-catenin antagonist with IC50 of 150 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 45 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 118 | In Stock |
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| 25MG | 259 | In Stock |
|
| 50MG | 363 | In Stock |
|
| 100MG | 529 | In Stock |
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| 500MG | 1152 | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePRI-724
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NoteResearch use only, not for human use.
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Brief DescriptionPRI-724 (PRI724)?is a potent, specific, second generation CBP/beta-catenin antagonist with IC50 of 150 nM.
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DescriptionPRI-724 (PRI724)?is a potent, specific, second generation CBP/beta-catenin antagonist with IC50 of 150 nM, an isomer or enantiomer of ICG-001; binds specifically to the co-activator CBP, but not to p300; selectively induce apoptosis in colon carcinoma cells but not in normal colon cells, and exhibits antitumor activity in the mouse xenograft models of colon cancer.Blood Cancer Phase 2 Clinical.
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In Vitro——
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In Vivo——
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SynonymsPRI 724 | PRI724
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PathwayWnt/Notch/Hedgehog
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TargetBeta-catenin
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RecptorWnt/β-catenin
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Research AreaCancer
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IndicationBlood cancer
Chemical Information
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CAS Number847591-62-2
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Formula Weight548.63
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Molecular FormulaC33H32N4O4
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Purity>98% (HPLC)
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SolubilityDMSO: 54.9 mg/mL (100 mM)；Ethanol: 27.4 mg/mL (50 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESC1CN([C@H]2CN(C(=O)[C@@H](N2C1=O)CC3=CC=C(C=C3)O)CC4=CC=CC5=CC=CC=C54)C(=O)NCC6=CC=CC=C6
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Chemical Name(6S,9aS)-N-benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sasaki T, et al. Transl Respir Med. 2014 Sep 11;2:8.
2. Zhang X, et al. Am J Cancer Res. 2015 Jul 15;5(8):2344-60.
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