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PRGL493

CAS No. 2479378-45-3

PRGL493( —— )

Catalog No. M34778 CAS No. 2479378-45-3

PRGL493 is an inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4).1It inhibits formation of arachidonoyl-CoA (AA-CoA) from arachidonic acid in, as well as the proliferation and migration of, PC3 and MDA-MB-231 cancer cells when used at a concentration of 50 μM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PRGL493
  • Note
    Research use only, not for human use.
  • Brief Description
    PRGL493 is an inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4).1It inhibits formation of arachidonoyl-CoA (AA-CoA) from arachidonic acid in, as well as the proliferation and migration of, PC3 and MDA-MB-231 cancer cells when used at a concentration of 50 μM.
  • Description
    PRGL493 is a potent and selective long-chain acyl-CoA synthetase 4 (ACSL4) inhibitor. PRGL493 blocks cell proliferation and tumor growth in both breast and prostate cellular and animal models. PRGL493 is used for cancer research.
  • In Vitro
    ——
  • In Vivo
    Animal Model:MDA-MB-231 or PC-3 cell suspensions mixed with Matrigel Matrix in a 3/1 dilution are injected into the right fank of NLAE:NIH(S)Fox1nu mice, aged 7-8?weeks Dosage:250?μg/kg Administration: Intraperitoneal?injection; 250?μg/kg; 43 and 34 consecutive days Result:Inhibited tumor growth in vivo models
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2479378-45-3
  • Formula Weight
    451.48
  • Molecular Formula
    C25H21N7O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 5 mg/mL (11.07 mM; Ultrasonic (<60°C)
  • SMILES
    CC(=O)NC1=NC(N2C(Nc3ccccc23)=N1)c1cn(nc1-c1ccc(C)o1)-c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ana F Castillo, et al. New inhibitor targeting Acyl-CoA synthetase 4 reduces breast and prostate tumor growth, therapeutic resistance and steroidogenesis. Cell Mol Life Sci. 2021 Mar;78(6):2893-2910.?
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