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PNU-120596

CAS No. 501925-31-1

PNU-120596( PNU-120596 | PNU 120596 | PNU120596 | NSC 216666 )

Catalog No. M18666 CAS No. 501925-31-1

PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 102 In Stock
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Biological Information

  • Product Name
    PNU-120596
  • Note
    Research use only, not for human use.
  • Brief Description
    PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.
  • Description
    PNU-120596, also known as NSC 216666, is α7 nicotinic acetylcholine receptor positive allosteric modulator. PNU-120596 reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats. PNU-120596 augments the effects of donepezil on learning and memory in aged rodents and non-human primates.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male Sprague Dawley rats (250-300 g) treated with Amphetamine Dosage:1 mg/kg Administration:Intravenous injection; once Result:Improved the auditory gating deficit caused by Amphetamine.
  • Synonyms
    PNU-120596 | PNU 120596 | PNU120596 | NSC 216666
  • Pathway
    Others
  • Target
    Thrombin
  • Recptor
    α7 nAChR
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    501925-31-1
  • Formula Weight
    311.72
  • Molecular Formula
    C13H14ClN3O4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 50 mg/mL 160.40 mM;
  • SMILES
    COc1cc(OC)c(NC(=O)Nc2noc(C)c2)cc1Cl
  • Chemical Name
    1-(5-Chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hurst RS,etal.A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization.J Neurosci. 2005 Apr 27;25(17):4396-405.
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  • PNU-120596

    PNU-120596 is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.

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