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PKR-IN-C16
CAS No. 608512-97-6
PKR-IN-C16 ( —— )
Catalog No. M22715 CAS No. 608512-97-6
PKR-IN-C16 is a specific protein kinase (PKR) inhibitor.?PKR-IN-C16 is able to inhibit the autophosphorylation of PKR and unlock the translation blockade induced by PKR in primary neuronal cultures.PKR-IN-C16 binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM.?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 46 | In Stock |
|
| 5MG | 72 | In Stock |
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| 10MG | 125 | In Stock |
|
| 25MG | 260 | In Stock |
|
| 50MG | 410 | In Stock |
|
| 100MG | 605 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePKR-IN-C16
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NoteResearch use only, not for human use.
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Brief DescriptionPKR-IN-C16 is a specific protein kinase (PKR) inhibitor.?PKR-IN-C16 is able to inhibit the autophosphorylation of PKR and unlock the translation blockade induced by PKR in primary neuronal cultures.PKR-IN-C16 binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM.?
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DescriptionPKR-IN-C16 is a specific protein kinase (PKR) inhibitor.?PKR-IN-C16 is able to inhibit the autophosphorylation of PKR and unlock the translation blockade induced by PKR in primary neuronal cultures.PKR-IN-C16 binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM.?PKR-IN-C16 protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress.?
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPKR
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Research Area——
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Indication——
Chemical Information
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CAS Number608512-97-6
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Formula Weight268.29
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Molecular FormulaC13H8N4OS
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Purity>98% (HPLC)
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SolubilityDMSO:15.67 mg/mL(58.41 mM)
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SMILESO=C1Nc2ccc3ncsc3c2\C1=C\c1cnc[nH]1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tronel C, et al. The specific PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component. Neurochem Int. 2014 Jan;64:73-83.
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