PKR-IN-C16

CAS No. 608512-97-6

PKR-IN-C16 ( —— )

Catalog No. M22715 CAS No. 608512-97-6

PKR-IN-C16 is a specific protein kinase (PKR) inhibitor.?PKR-IN-C16 is able to inhibit the autophosphorylation of PKR and unlock the translation blockade induced by PKR in primary neuronal cultures.PKR-IN-C16 binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 46 In Stock
5MG 72 In Stock
10MG 125 In Stock
25MG 260 In Stock
50MG 410 In Stock
100MG 605 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    PKR-IN-C16
  • Note
    Research use only, not for human use.
  • Brief Description
    PKR-IN-C16 is a specific protein kinase (PKR) inhibitor.?PKR-IN-C16 is able to inhibit the autophosphorylation of PKR and unlock the translation blockade induced by PKR in primary neuronal cultures.PKR-IN-C16 binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM.?
  • Description
    PKR-IN-C16 is a specific protein kinase (PKR) inhibitor.?PKR-IN-C16 is able to inhibit the autophosphorylation of PKR and unlock the translation blockade induced by PKR in primary neuronal cultures.PKR-IN-C16 binds the ATP-binding site of PKR and blocks autophosphorylation with an IC50 value of 186-210 nM.?PKR-IN-C16 protects human neuroblastoma cells against cell damage triggered by tunicamycin-mediated endoplasmic reticulum stress.?
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PKR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    608512-97-6
  • Formula Weight
    268.29
  • Molecular Formula
    C13H8N4OS
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:15.67 mg/mL(58.41 mM)
  • SMILES
    O=C1Nc2ccc3ncsc3c2\C1=C\c1cnc[nH]1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Tronel C, et al. The specific PKR inhibitor C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component. Neurochem Int. 2014 Jan;64:73-83.
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