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PK-7088
CAS No. 1446352-67-5
PK-7088( PK7088 )
Catalog No. M11898 CAS No. 1446352-67-5
PK-7088 is a small molecule mutant p53 Y220C reactivator.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePK-7088
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NoteResearch use only, not for human use.
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Brief DescriptionPK-7088 is a small molecule mutant p53 Y220C reactivator.
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DescriptionPK-7088 is a small molecule mutant p53 Y220C reactivator, promotes correct folding of Y220 mutant p53 and induces expression of p53 targets p21 and the Noxa, triggers nuclear export of the pro-apoptotic Bax protein to mitochondria.
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In Vitro——
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In Vivo——
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SynonymsPK7088
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PathwayApoptosis
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TargetMDM2-p53
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RecptorMDM2-p53
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Research Area——
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Indication——
Chemical Information
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CAS Number1446352-67-5
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Formula Weight223.279
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Molecular FormulaC14H13N3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 200 mg/mL (895.78 mM)
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SMILES——
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Chemical Name1-methyl-4-phenyl-3 -(1H-pyrrol-1-yl)-1H-pyrazole
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Liu X, et al. Nucleic Acids Res. 2013 Jul;41(12):6034-44.
2. Joerger AC, et al. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61.
3. Bykov VJ, et al. FEBS Lett. 2014 Aug 19;588(16):2622-7.
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