PK-7088

CAS No. 1446352-67-5

PK-7088( PK7088 )

Catalog No. M11898 CAS No. 1446352-67-5

PK-7088 is a small molecule mutant p53 Y220C reactivator.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PK-7088
  • Note
    Research use only, not for human use.
  • Brief Description
    PK-7088 is a small molecule mutant p53 Y220C reactivator.
  • Description
    PK-7088 is a small molecule mutant p53 Y220C reactivator, promotes correct folding of Y220 mutant p53 and induces expression of p53 targets p21 and the Noxa, triggers nuclear export of the pro-apoptotic Bax protein to mitochondria.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PK7088
  • Pathway
    Apoptosis
  • Target
    MDM2-p53
  • Recptor
    MDM2-p53
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1446352-67-5
  • Formula Weight
    223.279
  • Molecular Formula
    C14H13N3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 200 mg/mL (895.78 mM)
  • SMILES
    ——
  • Chemical Name
    1-methyl-4-phenyl-3 -(1H-pyrrol-1-yl)-1H-pyrazole

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Liu X, et al. Nucleic Acids Res. 2013 Jul;41(12):6034-44. 2. Joerger AC, et al. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. 3. Bykov VJ, et al. FEBS Lett. 2014 Aug 19;588(16):2622-7.
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