Cart
sales@molnova.com
PK-7088
CAS No. 1446352-67-5
PK-7088( PK7088 )
Catalog No. M11898 CAS No. 1446352-67-5
PK-7088 is a small molecule mutant p53 Y220C reactivator.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NamePK-7088
-
NoteResearch use only, not for human use.
-
Brief DescriptionPK-7088 is a small molecule mutant p53 Y220C reactivator.
-
DescriptionPK-7088 is a small molecule mutant p53 Y220C reactivator, promotes correct folding of Y220 mutant p53 and induces expression of p53 targets p21 and the Noxa, triggers nuclear export of the pro-apoptotic Bax protein to mitochondria.
-
In Vitro——
-
In Vivo——
-
SynonymsPK7088
-
PathwayApoptosis
-
TargetMDM2-p53
-
RecptorMDM2-p53
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1446352-67-5
-
Formula Weight223.279
-
Molecular FormulaC14H13N3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 200 mg/mL (895.78 mM)
-
SMILES——
-
Chemical Name1-methyl-4-phenyl-3 -(1H-pyrrol-1-yl)-1H-pyrazole
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Liu X, et al. Nucleic Acids Res. 2013 Jul;41(12):6034-44.
2. Joerger AC, et al. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61.
3. Bykov VJ, et al. FEBS Lett. 2014 Aug 19;588(16):2622-7.
molnova catalog
related products
-
MB725
MB725 is a small-molecule p53 mutant Y220C stabilizer, induces selective viability reduction in several p53-Y220C cancer cell lines (Huh7 cell IC50=10 uM).
-
Nutlin-3b
A p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM.
-
MD-224
MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.
