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PHGDH-IN-3
CAS No. 2893778-31-7
PHGDH-IN-3( —— )
Catalog No. M36500 CAS No. 2893778-31-7
PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.8 μM against PHGDH, and it can be used in cancer research.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 149 | In Stock |
|
| 5MG | 227 | In Stock |
|
| 10MG | 337 | In Stock |
|
| 25MG | 523 | In Stock |
|
| 50MG | 701 | In Stock |
|
| 100MG | 888 | In Stock |
|
| 500MG | 1782 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePHGDH-IN-3
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NoteResearch use only, not for human use.
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Brief DescriptionPHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.8 μM against PHGDH, and it can be used in cancer research.
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DescriptionPHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor. PHGDH-IN-3 inhibits PHGDH with an IC50 value of 2.8 μM. PHGDH-IN-3 can be used for the research of cancer.
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In Vitro——
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In VivoAnimal Model:Balb/c nude mice Dosage:12.5, 25, 50 mg/kg Administration:Intraperitoneal (i.p.); once daily for consecutive 31 days Result:Exhibited an in vivo anti-tumor effect and significantly delayed the tumor growth.Significantly abated the tumor weights of mice at 25 mg/ kg.
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Synonyms——
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PathwayMetabolic Enzyme/Protease
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TargetDehydrogenase
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RecptorDehydrogenase
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Research Area——
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Indication——
Chemical Information
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CAS Number2893778-31-7
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Formula Weight495.55
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Molecular FormulaC24H18FN3O4S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (201.80 mM; Ultrasonic (<70°C)
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SMILESN(C(=O)C1=CC=C(S(NC2=CC(C(C)=O)=CC=C2)(=O)=O)C=C1)C3=NC(=CS3)C4=CC(F)=CC=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Dingding Gao, et al. Discovery of Novel Drug-like PHGDH Inhibitors to Disrupt Serine Biosynthesis for Cancer Therapy. J Med Chem. 2023 Jan 12;66(1):285-305.?
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