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Home - Products - Cell Cycle/DNA Damage - Aurora Kinase - PHA-680632

PHA-680632

CAS No. 398493-79-3

PHA-680632( PHA680632 | PHA 680632 )

Catalog No. M14369 CAS No. 398493-79-3

A potent, highly selective Aurora kinase inhibitor with IC50 of 27, 135 and 120 nM for Aurora A, B and C, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PHA-680632
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, highly selective Aurora kinase inhibitor with IC50 of 27, 135 and 120 nM for Aurora A, B and C, respectively.
  • Description
    A potent, highly selective Aurora kinase inhibitor with IC50 of 27, 135 and 120 nM for Aurora A, B and C, respectively; exhibits at least 30- to 200-fold selectivity against a panel of 22 kinases compared with Aurora A; has potent antiproliferative activity in a wide range of cancer cell types (IC50=0.06-7.15 uM); shows significant tumor growth inhibition in different animal tumor models at well-tolerated doses.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PHA680632 | PHA 680632
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Aurora Kinase
  • Recptor
    Aurora A| Aurora B| Aurora C| FGFR1| PLK1
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    398493-79-3
  • Formula Weight
    501.6232
  • Molecular Formula
    C28H35N7O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 30 mg/mL
  • SMILES
    O=C(N(C1)CC2=C1C(NC(C3=CC=C(N4CCN(C)CC4)C=C3)=O)=NN2)NC5=C(CC)C=CC=C5CC
  • Chemical Name
    Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-(2,6-diethylphenyl)-4,6-dihydro-3-[[4-(4-methyl-1-piperazinyl)benzoyl]amino]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Soncini C, et al. Clin Cancer Res. 2006 Jul 1;12(13):4080-9. 2. Tao Y, et al. Br J Cancer. 2007 Dec 17;97(12):1664-72. 3. Ratushny V, et al. Oncogene. 2012 Mar 8;31(10):1217-27.
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