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Home - Products - Cell Cycle/DNA Damage - Aurora Kinase - Tozasertib

Tozasertib

CAS No. 639089-54-6

Tozasertib( MK-0457 | VX-680 | MK0457 | VX680 | VX 680 | MK 0457 )

Catalog No. M15426 CAS No. 639089-54-6

Tozasertib (MK-0457, VX-680) is a highly potent, selective and reversible Aurora kinase inhibitor with Ki of 0.6, 18 and 4.6 nM for Aurora A, B and C, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Tozasertib
  • Note
    Research use only, not for human use.
  • Brief Description
    Tozasertib (MK-0457, VX-680) is a highly potent, selective and reversible Aurora kinase inhibitor with Ki of 0.6, 18 and 4.6 nM for Aurora A, B and C, respectively.
  • Description
    Tozasertib (MK-0457, VX-680) is a highly potent, selective and reversible Aurora kinase inhibitor with Ki of 0.6, 18 and 4.6 nM for Aurora A, B and C, respectively; also inhibits the imatinib-resistant ABL(T315I) kinase with Kd of 5 nM, displays >100-fold selectivity for the Aurora-A kinase over 55 other kinases with the only exception FLT-3 (Ki=30 nM); blocks cell-cycle progression and induces apoptosis in a diverse range of human tumor types; causes profound inhibition of tumor growth in a variety of in vivo xenograft models.Blood Cancer Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    MK-0457 | VX-680 | MK0457 | VX680 | VX 680 | MK 0457
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Aurora Kinase
  • Recptor
    AuroraA|AuroraB|AuroraC|Bcr-Abl|FLT3
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    639089-54-6
  • Formula Weight
    464.5864
  • Molecular Formula
    C23H28N8OS
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O=C(C1CC1)NC2=CC=C(SC3=NC(NC4=CC(C)=NN4)=CC(N5CCN(C)CC5)=N3)C=C2
  • Chemical Name
    Cyclopropanecarboxamide, N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Harrington EA, et al. Nat Med. 2004 Mar;10(3):262-7. 2. Young MA, et al. Cancer Res. 2006 Jan 15;66(2):1007-14. 3. Carter TA, et al. Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11011-6. 4. Giles FJ, et al. Blood. 2007 Jan 15;109(2):500-2.
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