PGD2-inhibitor( MDK66671 | MDK-66671 MDK 66671 )

Catalog No. M19229 CAS No. 885066-67-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PGD2-inhibitor
Note

Research use only, not for human use.
Brief Description

MDK66671 is a prostaglandin D2（PGD2) inhibitor. MDK66671 has CAS#885066-67-1, in which the last five digit was used in its name.
Description

MDK66671 is a prostaglandin D2（PGD2) inhibitor. MDK66671 has CAS#885066-67-1, in which the last five digit was used in its name.
In Vitro

Prostaglandin D2 (PGD2) is a major inflammatory mediator implicated in asthma and allergic rhinitis. It is largely produced as the major cyclooxygenase metabolite upon allergen-provoked degranulation from mast cells. Blockage of PGD2 using DP antagonists has been shown to be effective at alleviating the symptoms of allergic rhinitis in multiple species and more specifically has been shown to inhibit the antigen-induced nasal congestion.
In Vivo

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Synonyms

MDK66671 | MDK-66671 MDK 66671
Pathway

Others
Target

Other Targets
Recptor

PGD2(DP)
Research Area

——
Indication

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CAS Number

885066-67-1
Formula Weight

460.35
Molecular Formula

C23H23Cl2N3O3
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 25 mg/mL; 54.31 mM
SMILES

COc2nc(cc(NCCc1ccc(Cl)cc1Cl)n2)c3cccc(c3)C(C)(C)C(=O)O
Chemical Name

2-(3-(6-((2,4-dichlorophenethyl)amino)-2-methoxypyrimidin-4-yl)phenyl)-2-methylpropanoic acid

1.Mu L, et al. Understanding DP receptor antagonism using a CoMSIA approach. Bioorg Med Chem Lett. 2011 Jan 1;21(1):66-75.

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