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PG-S3-001
CAS No. 2047372-50-7
PG-S3-001( —— )
Catalog No. M13182 CAS No. 2047372-50-7
PG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePG-S3-001
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NoteResearch use only, not for human use.
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Brief DescriptionPG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance.
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DescriptionPG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance; shows no effect in a kinome screen (>100 cancer-relevant kinases); inhibits phosphorylation of STAT3 at Y705, inhibits patient-derived pancreatic cancer cell proliferation in vitro and in vivo in the low micromolar range; exhibits in vivo efficacy on pancreatic cancer xenografts.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayJAK/STAT Signaling
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TargetSTAT
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RecptorSTAT
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Research Area——
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Indication——
Chemical Information
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CAS Number2047372-50-7
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Formula Weight652.677
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Molecular FormulaC32H33F5N2O5S
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name4-{(4-Cyclohexyl-benzyl)-[3-methyl-2-(methyl-pentafluorobenzenesulfonyl-amino)-butyryl]-amino}-benzoic acid
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Arpin CC, et al. Mol Cancer Ther. 2016 May;15(5):794-805.
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