Cart
sales@molnova.com
Home - Products - JAK/STAT Signaling - STAT - PG-S3-001

PG-S3-001

CAS No. 2047372-50-7

PG-S3-001( —— )

Catalog No. M13182 CAS No. 2047372-50-7

PG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    PG-S3-001
  • Note
    Research use only, not for human use.
  • Brief Description
    PG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance.
  • Description
    PG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance; shows no effect in a kinome screen (>100 cancer-relevant kinases); inhibits phosphorylation of STAT3 at Y705, inhibits patient-derived pancreatic cancer cell proliferation in vitro and in vivo in the low micromolar range; exhibits in vivo efficacy on pancreatic cancer xenografts.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2047372-50-7
  • Formula Weight
    652.677
  • Molecular Formula
    C32H33F5N2O5S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    4-{(4-Cyclohexyl-benzyl)-[3-methyl-2-(methyl-pentafluorobenzenesulfonyl-amino)-butyryl]-amino}-benzoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Arpin CC, et al. Mol Cancer Ther. 2016 May;15(5):794-805.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Piperlongumine

    A naturally occurring small molecule recently identified to be toxic selectively to cancer cells in vitro and in vivo.

  • STAT3 inhibitor C188

    A potent, selective STAT3 inhibitor that blocks STAT3 binding to its phosphopeptide ligand (IC50=20 uM).

  • SD-1029

    SD-1029 (NSC 371488) is a potent inhibitor of Stat3 activation.

Sign In Join Free