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Home - Products - JAK/STAT Signaling - STAT - PG-S3-001

PG-S3-001

CAS No. 2047372-50-7

PG-S3-001( —— )

Catalog No. M13182 CAS No. 2047372-50-7

PG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PG-S3-001
  • Note
    Research use only, not for human use.
  • Brief Description
    PG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance.
  • Description
    PG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance; shows no effect in a kinome screen (>100 cancer-relevant kinases); inhibits phosphorylation of STAT3 at Y705, inhibits patient-derived pancreatic cancer cell proliferation in vitro and in vivo in the low micromolar range; exhibits in vivo efficacy on pancreatic cancer xenografts.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2047372-50-7
  • Formula Weight
    652.677
  • Molecular Formula
    C32H33F5N2O5S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    4-{(4-Cyclohexyl-benzyl)-[3-methyl-2-(methyl-pentafluorobenzenesulfonyl-amino)-butyryl]-amino}-benzoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Arpin CC, et al. Mol Cancer Ther. 2016 May;15(5):794-805.
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