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OF-1

CAS No. 919973-83-4

OF-1 ( SGC OF-1; SGC OF 1; SGC OF1; SGCOF1; SGC-OF-1; OF-1 )

Catalog No. M16600 CAS No. 919973-83-4

OF-1 is a potent bromodomain inhibitor that inhibits BRPF1B/2/3 bromodomains with Kd of 0.1/0.5/2.4 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    OF-1
  • Note
    Research use only, not for human use.
  • Brief Description
    OF-1 is a potent bromodomain inhibitor that inhibits BRPF1B/2/3 bromodomains with Kd of 0.1/0.5/2.4 uM.
  • Description
    OF-1 is a potent bromodomain inhibitor that inhibits BRPF1B/2/3 bromodomains with Kd of 0.1/0.5/2.4 uM; displays good selectivity against other bromodomains, 39-fold selectivity over closest off-target BRD4.
  • Synonyms
    SGC OF-1; SGC OF 1; SGC OF1; SGCOF1; SGC-OF-1; OF-1
  • Pathway
    Chromatin/Epigenetic
  • Target
    Bromodomain
  • Recptor
    BRPF1B;BRPF2
  • Research Area
    Other Indications
  • Indication
    ——

Chemical Information

  • CAS Number
    919973-83-4
  • Formula Weight
    440.31
  • Molecular Formula
    C17H18BrN3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 8.8 mg/mL (20 mM) （ < 1 mg/ml refers to the product slightly soluble or insoluble )
  • SMILES
    O=S(C1=CC=C(Br)C=C1C)(NC2=C(OC)C=C(N3C)C(N(C)C3=O)=C2)=O
  • Chemical Name
    4-bromo-N-(6-methoxy-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-2-methylbenzenesulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Demont EH, et al. ACS Med Chem Lett. 2014 Sep 10;5(11):1190-5.
2. Pérez-Salvia M, et al. Epigenetics. 2017 May 4;12(5):323-339.
3.Meier JC, et al. ACS Chem Biol. 2017 Oct 20;12(10):2619-2630.
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