PF-9184 ( PF9184 )

Catalog No. M10842 CAS No. 1221971-47-6

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PF-9184
Note

Research use only, not for human use.
Brief Description

PF-9184 is a potent, selective mPGES-1 (microsomal prostaglandin E synthase-1) inhibitor with IC50 of 16.5 nM.
Description

PF-9184 is a potent, selective mPGES-1 (microsomal prostaglandin E synthase-1) inhibitor with IC50 of 16.5 nM; shows no effect against COX-1 and COX-2 (>6,500-fold selectivity); inhibits PGE2 synthesis in serum-free cell and human whole blood cultures with IC50 of 0.5-5 uM, while sparing the synthesis of PGF(1alpha)) and PGF(2alpha).
Synonyms

PF9184
Pathway

Immunology/Inflammation
Target

PGE synthase
Recptor

PGE synthase
Research Area

——
Indication

——

CAS Number

1221971-47-6
Formula Weight

461.30
Molecular Formula

C21H14Cl2N2O4S
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=C(O)C2=CC=CC=C2S(N1)(=O)=O)NC3=CC=C(C4=CC=C(Cl)C(Cl)=C4)C=C3
Chemical Name

2H-1,2-Benzothiazine-3-carboxamide, N-(3',4'-dichloro[1,1'-biphenyl]-4-yl)-4-hydroxy-,1,1-dioxide

1. Mbalaviele G, et al. Biochem Pharmacol. 2010 May 15;79(10):1445-54.
2. Chang HH, et al. Future Med Chem. 2011 Nov;3(15):1909-34.

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