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PF-8380
CAS No. 1144035-53-9
PF-8380 ( PF8380; PF-8380; PF 8380 )
Catalog No. M10512 CAS No. 1144035-53-9
Potent autotaxin inhibitor (IC50= 2.8 nM in isolated enzyme assay; 101 nM in human whole blood).
Purity : >98%(HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 35 | In Stock |
|
| 10MG | 58 | In Stock |
|
| 25MG | 125 | In Stock |
|
| 50MG | 205 | In Stock |
|
| 100MG | 335 | In Stock |
|
| 200MG | 494 | In Stock |
|
| 500MG | 782 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePF-8380
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NoteResearch use only, not for human use.
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Brief DescriptionPotent autotaxin inhibitor (IC50= 2.8 nM in isolated enzyme assay; 101 nM in human whole blood).
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DescriptionPotent autotaxin inhibitor (IC50= 2.8 nM in isolated enzyme assay; 101 nM in human whole blood). Modulates lysophosphatidic acid (LPA) levelsin vivoandin vitroby directly inhibiting autotaxin; reduces LPA levels both in plasma and at site of inflammation. Orally available.
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SynonymsPF8380; PF-8380; PF 8380
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PathwayAngiogenesis
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TargetPDE
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RecptorAutotaxin
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number1144035-53-9
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Formula Weight478.33
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Molecular FormulaC22H21Cl2N3O5
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Purity>98%(HPLC)
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SolubilityDMSO: 95 mg/mL (198.6 mM)
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SMILESO=C(N1CCN(CCC(C2=CC=C3NC(OC3=C2)=O)=O)CC1)OCC4=CC(Cl)=CC(Cl)=C4
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Chemical Name3,5-dichlorobenzyl 4-(3-oxo-3-(2-oxo-2,3-dihydrobenzo[d]oxazol-6-yl)propyl)piperazine-1-carboxylate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gierse J, et al. J Pharmacol Exp Ther. 2010, 334(1):310-317.
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