MY-5445
CAS No. 78351-75-4
MY-5445 ( N-(3-chlorophenyl)-4-phenylphthalazin-1-amine )
Catalog No. M26765 CAS No. 78351-75-4
MY-5445 is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki:1.3 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 36 | Get Quote |
|
5MG | 58 | Get Quote |
|
10MG | 87 | Get Quote |
|
25MG | 146 | Get Quote |
|
50MG | 214 | Get Quote |
|
100MG | Get Quote | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameMY-5445
-
NoteResearch use only, not for human use.
-
Brief DescriptionMY-5445 is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki:1.3 μM).
-
DescriptionMY-5445 is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki:1.3 μM).(In Vitro): in ABCG2-overexpressing cells, MY-5445 selectively reverses ABCG2-mediated multidrug resistance. MY-5445 reverses ABCG2-mediated multidrug resistance (MDR) by potentiating the cytotoxicity of an ABCG2 substrate drug in ABCG2-overexpressing multidrug-resistant cancer cells, possibly by modulating the function and/or the protein expression of ABCG2. In the S1-M1-80 cell, MY-5445 (3 μM; 48 hours) substantially increases the topotecan-induced apoptosis.(In Vivo):I.p administration of 0.5-3 mg/kg twice a day for 15 days) produces significant relief of mechanical hypersensitivity.
-
SynonymsN-(3-chlorophenyl)-4-phenylphthalazin-1-amine
-
PathwayAngiogenesis
-
TargetPDE
-
RecptorDHFR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number78351-75-4
-
Formula Weight331.8
-
Molecular FormulaC20H14ClN3
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESClc1cccc(Nc2nnc(-c3ccccc3)c3ccccc23)c1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Hopper AT, et al. Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis. J Med Chem. 2019;62(3):1562-1576.
molnova catalog
related products
-
RPL-554
RPL-554 (LS-193855, RPL554)is a potent, orally available, dual PDE3/PDE4 inhibitor with IC50 of 0.4 nM and 1479 nM, respectively.
-
MR-L2
MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).
-
Cilomilast
A potent and selective PDE4 inhibitor with IC50 of 95/120 nM for LPDE4/HPDE4.