MY-5445
CAS No. 78351-75-4
MY-5445 ( N-(3-chlorophenyl)-4-phenylphthalazin-1-amine )
Catalog No. M26765 CAS No. 78351-75-4
MY-5445 is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki:1.3 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 36 | Get Quote |
|
5MG | 58 | Get Quote |
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10MG | 87 | Get Quote |
|
25MG | 146 | Get Quote |
|
50MG | 214 | Get Quote |
|
100MG | Get Quote | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameMY-5445
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NoteResearch use only, not for human use.
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Brief DescriptionMY-5445 is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki:1.3 μM).
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DescriptionMY-5445 is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki:1.3 μM).(In Vitro): in ABCG2-overexpressing cells, MY-5445 selectively reverses ABCG2-mediated multidrug resistance. MY-5445 reverses ABCG2-mediated multidrug resistance (MDR) by potentiating the cytotoxicity of an ABCG2 substrate drug in ABCG2-overexpressing multidrug-resistant cancer cells, possibly by modulating the function and/or the protein expression of ABCG2. In the S1-M1-80 cell, MY-5445 (3 μM; 48 hours) substantially increases the topotecan-induced apoptosis.(In Vivo):I.p administration of 0.5-3 mg/kg twice a day for 15 days) produces significant relief of mechanical hypersensitivity.
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SynonymsN-(3-chlorophenyl)-4-phenylphthalazin-1-amine
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PathwayAngiogenesis
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TargetPDE
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RecptorDHFR
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Research Area——
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Indication——
Chemical Information
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CAS Number78351-75-4
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Formula Weight331.8
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Molecular FormulaC20H14ClN3
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Purity>98% (HPLC)
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Solubility——
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SMILESClc1cccc(Nc2nnc(-c3ccccc3)c3ccccc23)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Hopper AT, et al. Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis. J Med Chem. 2019;62(3):1562-1576.
molnova catalog
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