MY-5445

CAS No. 78351-75-4

MY-5445 ( N-(3-chlorophenyl)-4-phenylphthalazin-1-amine )

Catalog No. M26765 CAS No. 78351-75-4

MY-5445 is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki:1.3 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 36 Get Quote
5MG 58 Get Quote
10MG 87 Get Quote
25MG 146 Get Quote
50MG 214 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    MY-5445
  • Note
    Research use only, not for human use.
  • Brief Description
    MY-5445 is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki:1.3 μM).
  • Description
    MY-5445 is a specific inhibitor of phosphodiesterase type 5 (PDE5). MY-5445 selectively inhibits cGMP PDE (Ki:1.3 μM).(In Vitro): in ABCG2-overexpressing cells, MY-5445 selectively reverses ABCG2-mediated multidrug resistance. MY-5445 reverses ABCG2-mediated multidrug resistance (MDR) by potentiating the cytotoxicity of an ABCG2 substrate drug in ABCG2-overexpressing multidrug-resistant cancer cells, possibly by modulating the function and/or the protein expression of ABCG2. In the S1-M1-80 cell, MY-5445 (3 μM; 48 hours) substantially increases the topotecan-induced apoptosis.(In Vivo):I.p administration of 0.5-3 mg/kg twice a day for 15 days) produces significant relief of mechanical hypersensitivity.
  • Synonyms
    N-(3-chlorophenyl)-4-phenylphthalazin-1-amine
  • Pathway
    Angiogenesis
  • Target
    PDE
  • Recptor
    DHFR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    78351-75-4
  • Formula Weight
    331.8
  • Molecular Formula
    C20H14ClN3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Clc1cccc(Nc2nnc(-c3ccccc3)c3ccccc23)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hopper AT, et al. Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis. J Med Chem. 2019;62(3):1562-1576.
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