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PF-2545920 hydrochloride
CAS No. ——
PF-2545920 hydrochloride( Mardepodect hydrochloride | MP-10 hydrochloride | PF-02545920 hydrochloride )
Catalog No. M16961 CAS No. ——
A potent and selective PDE10A inhibitor with IC50 of 0.37 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePF-2545920 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective PDE10A inhibitor with IC50 of 0.37 nM.
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DescriptionA potent and selective PDE10A inhibitor with IC50 of 0.37 nM; displays >1,000-fold selectivity over the PDEs; antagonizes apomorphine-induced climbing in mice, inhibits conditioned avoidance responding in both rats and mice, and blocks NMDA antagonist-induced deficits in prepulse inhibition of acoustic startle response in rats; dose-dependently increases c-Fos immunopositive nuclei in all regions of neostriatum in the DRd1a-tdTomato mice; improves cortico-basal ganglia function in huntington's disease models; orally bioavailable.Schizophrenia Phase 2 Discontinued.
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In Vitro——
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In Vivo——
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SynonymsMardepodect hydrochloride | MP-10 hydrochloride | PF-02545920 hydrochloride
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight428.9135
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Molecular FormulaC25H21ClN4O
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Purity>98% (HPLC)
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SolubilityDMSO
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SMILES——
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Chemical NameQuinoline, 2-[[4-[1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]-,hydrochloride(1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Verhoest PR, et al. J Med Chem. 2009 Aug 27;52(16):5188-96.
2. Grauer SM, et al. J Pharmacol Exp Ther. 2009 Nov;331(2):574-90.
3. Beaumont V, et al. Neuron. 2016 Dec 21;92(6):1220-1237.
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