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8-Chloroadenosine
CAS No. 34408-14-5
8-Chloroadenosine ( 8 Chloroadenosine; 8Chloroadenosine; NSC-354258; NSC 354258; NSC354258; 8-Cl-Ado )
Catalog No. M27123 CAS No. 34408-14-5
8-Chloroadenosine is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 87 | Get Quote |
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| 5MG | 149 | Get Quote |
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| 10MG | 238 | Get Quote |
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| 25MG | 403 | Get Quote |
|
| 50MG | 555 | Get Quote |
|
| 100MG | 795 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product Name8-Chloroadenosine
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NoteResearch use only, not for human use.
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Brief Description8-Chloroadenosine is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia.
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Description8-Chloroadenosine is a 5' AMP-activated protein kinase agonist potentially for the treatment of chronic lymphocytic leukemia. 8-chloroadenosine activity is associated with inhibition of the mTOR pathway.8-Chloroadenosine is a nucleoside analog; metabolized in vivo to 8-Chloro-ATP. Incorporates into RNA during transcription and inhibits RNA synthesis. Exhibits cytotoxicity in MM.1S, RPMI-8226, and U266 cancer cell lines; induces G2/M cell cycle arrest and mitotic catastrophe in A549 and H1299 cells. 8-Chloroadenosine has been shown to deplete ATP and inhibit tumor growth in hematological malignancies as well as in lung and breast cancer cell lines.
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Synonyms8 Chloroadenosine; 8Chloroadenosine; NSC-354258; NSC 354258; NSC354258; 8-Cl-Ado
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PathwayMembrane Transporter/Ion Channel
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TargetAMPK
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number34408-14-5
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Formula Weight301.7
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Molecular FormulaC10H12ClN5O4
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Purity>98% (HPLC)
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Solubility——
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SMILESNc1ncnc2n([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c(Cl)nc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Staňková P, et al. The toxic effect of thioacetamide on rat liver in vitro. Toxicol In Vitro. 2010 Dec;24(8):2097-103.
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