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PF-06747775
CAS No. 1776112-90-3
PF-06747775 ( PF 06747775;PF06747775;PF 6747775 )
Catalog No. M12674 CAS No. 1776112-90-3
A potent, selective, irreversible EGFR mutants with IC50 of 12, 3, 4 and 5 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 656 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePF-06747775
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, irreversible EGFR mutants with IC50 of 12, 3, 4 and 5 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively.
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DescriptionA potent, selective, irreversible EGFR mutants with IC50 of 12, 3, 4 and 5 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively; displays excellent selectivity over wild-type EGFR (IC50=307 nM), and desirable ADME properties, shows potential for treatment of EGFR T790M mutation in advanced NSCLC.Lung Cancer Phase 2 Clinical
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SynonymsPF 06747775;PF06747775;PF 6747775
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR
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Research AreaCancer
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IndicationLung Cancer
Chemical Information
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CAS Number1776112-90-3
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Formula Weight415.43
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Molecular FormulaC18H22FN9O2
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Purity>98% (HPLC)
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Solubility——
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SMILESC=CC(N[C@@H]1CN(C2=NC(NC3=CN(C)N=C3OC)=C4N=CN(C)C4=N2)C[C@H]1F)=O
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Chemical NameN-((3R,4R)-4-fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidin-3-yl)acrylamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Planken S, et al. J Med Chem. 2017 Apr 13;60(7):3002-3019.
2. Patel H, et al. Eur J Med Chem. 2017 May 11. pii: S0223-5234(17)30388-4.
3. Wang S, et al. J Hematol Oncol. 2016 Apr 12;9:34.
2. Patel H, et al. Eur J Med Chem. 2017 May 11. pii: S0223-5234(17)30388-4.
3. Wang S, et al. J Hematol Oncol. 2016 Apr 12;9:34.
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