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PF-06446846

CAS No. 1632250-49-7

PF-06446846 ( —— )

Catalog No. M22373 CAS No. 1632250-49-7

PF?06446846 is a potent and selective PCSK9 inhibitor?PF-06446846 reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PF-06446846
  • Note
    Research use only, not for human use.
  • Brief Description
    PF?06446846 is a potent and selective PCSK9 inhibitor?PF-06446846 reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing.?
  • Description
    PF?06446846 is a potent and selective PCSK9 inhibitor?PF-06446846 reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing.?PF-06446846 is highly selective for the inhibition of PCSK9 translation.?The mechanism of action employed by PF-06446846 reveals a previously unexpected tunability of the human ribosome that allows small molecules to specifically block translation of individual transcripts.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    PCSK9
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1632250-49-7
  • Formula Weight
    433.9
  • Molecular Formula
    C22H20ClN7O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    Clc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-n1nnc2cccnc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lintner N G , Mcclure K F , Donna P , et al. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain[J]. PLoS Biology, 2017, 15(3):e2001882-.
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