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PF-06446846
CAS No. 1632250-49-7
PF-06446846 ( —— )
Catalog No. M22373 CAS No. 1632250-49-7
PF?06446846 is a potent and selective PCSK9 inhibitor?PF-06446846 reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing.?
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 120 | In Stock |
|
| 5MG | 176 | In Stock |
|
| 10MG | 266 | In Stock |
|
| 25MG | 489 | In Stock |
|
| 50MG | 705 | In Stock |
|
| 100MG | 981 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePF-06446846
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NoteResearch use only, not for human use.
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Brief DescriptionPF?06446846 is a potent and selective PCSK9 inhibitor?PF-06446846 reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing.?
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DescriptionPF?06446846 is a potent and selective PCSK9 inhibitor?PF-06446846 reduces plasma PCSK9 and total cholesterol levels in rats following oral dosing.?PF-06446846 is highly selective for the inhibition of PCSK9 translation.?The mechanism of action employed by PF-06446846 reveals a previously unexpected tunability of the human ribosome that allows small molecules to specifically block translation of individual transcripts.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPCSK9
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Research Area——
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Indication——
Chemical Information
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CAS Number1632250-49-7
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Formula Weight433.9
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Molecular FormulaC22H20ClN7O
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Purity>98% (HPLC)
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Solubility——
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SMILESClc1cccnc1N([C@@H]1CCCNC1)C(=O)c1ccc(cc1)-n1nnc2cccnc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Lintner N G , Mcclure K F , Donna P , et al. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain[J]. PLoS Biology, 2017, 15(3):e2001882-.
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