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PF-06260933
CAS No. 1811510-56-1
PF-06260933( PF 6260933 | PF6260933 )
Catalog No. M12779 CAS No. 1811510-56-1
PF-06260933 (PF06260933,PF6260933) is a potent, selective, orally available MAP4K4 inhibitor with IC50 of 3.7 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 52 | In Stock |
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| 5MG | 95 | In Stock |
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| 10MG | 149 | In Stock |
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| 25MG | 308 | In Stock |
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| 50MG | 492 | In Stock |
|
| 100MG | 710 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePF-06260933
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NoteResearch use only, not for human use.
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Brief DescriptionPF-06260933 (PF06260933,PF6260933) is a potent, selective, orally available MAP4K4 inhibitor with IC50 of 3.7 nM.
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DescriptionPF-06260933 (PF06260933,PF6260933) is a potent, selective, orally available MAP4K4 inhibitor with IC50 of 3.7 nM; demonstrates very good selectivity against more than 150 native kinases, with only the closely related GCK family members (ZC2, TNIK and ZC3, MINK 70% inhibition at 1 uM); inhibits LPS-induced plasma TNFα levels in mouse model.
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In Vitro——
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In Vivo——
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SynonymsPF 6260933 | PF6260933
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PathwayMAPK/ERK Signaling
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TargetMAP4K
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RecptorMAP4K4forCell|MAP4K4forKinase|MAP4K4
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Research Area——
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Indication——
Chemical Information
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CAS Number1811510-56-1
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Formula Weight296.754
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Molecular FormulaC16H13ClN4
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESC1=CC(=CC=C1C2=C(N=CC(=C2)C3=CN=C(C=C3)N)N)Cl
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Chemical Name5-(4-chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ammirati M, et al. ACS Med Chem Lett. 2015 Oct 6;6(11):1128-33.
2. Roth Flach RJ, et al. Nat Commun. 2015 Dec 21;6:8995.
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