PF-05150122( PF05150122 )

Catalog No. M10944 CAS No. 1235406-03-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PF-05150122
Note

Research use only, not for human use.
Brief Description

PF-05150122 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM.
Description

PF-05150122 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.Pain Phase 1 Discontinued.
In Vitro

PF-05186462 inhibits human Nav1.7 channels (IC50=21 nM) in HEK293 cells.PF-05186462 exhibits a high plasma protein binding rate.
In Vivo

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Synonyms

PF05150122
Pathway

Membrane Transporter/Ion Channel
Target

Sodium Channel
Recptor

Sodium Channel
Research Area

Neurological Disease
Indication

Pain

CAS Number

1235406-03-7
Formula Weight

531.885
Molecular Formula

C19H10ClF4N5O3S2
Purity

>98% (HPLC)
Solubility

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SMILES

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Chemical Name

5-chloro-2-fluoro-4-(2-(pyridazin-4-yl)-4-(trifluoromethyl)phenoxy)-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

1. Swain NA, et al. J Med Chem. 2017 Aug 24;60(16):7029-7042. 2. Jones HM, et al. Clin Pharmacokinet. 2016 Jul;55(7):875-87.

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