Cart
sales@molnova.com
Home - Products - Membrane Transporter/Ion Channel - Sodium Channel - PF-05150122

PF-05150122

CAS No. 1235406-03-7

PF-05150122( PF05150122 )

Catalog No. M10944 CAS No. 1235406-03-7

PF-05150122 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 272 Get Quote
10MG 408 Get Quote
25MG 672 Get Quote
50MG 945 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    PF-05150122
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-05150122 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM.
  • Description
    PF-05150122 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.Pain Phase 1 Discontinued.
  • In Vitro
    PF-05186462 inhibits human Nav1.7 channels (IC50=21 nM) in HEK293 cells.PF-05186462 exhibits a high plasma protein binding rate.
  • In Vivo
    ——
  • Synonyms
    PF05150122
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Sodium Channel
  • Recptor
    Sodium Channel
  • Research Area
    Neurological Disease
  • Indication
    Pain

Chemical Information

  • CAS Number
    1235406-03-7
  • Formula Weight
    531.885
  • Molecular Formula
    C19H10ClF4N5O3S2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    5-chloro-2-fluoro-4-(2-(pyridazin-4-yl)-4-(trifluoromethyl)phenoxy)-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Swain NA, et al. J Med Chem. 2017 Aug 24;60(16):7029-7042. 2. Jones HM, et al. Clin Pharmacokinet. 2016 Jul;55(7):875-87.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • ABBV-318

    ABBV-318 can be used as small molecule Nav1.7/Nav1.8 blockers for the treatment of pain, with IC50 values of 2.8 μM for hNav1.7 and 3.8 μM for hNav1.8. ABBV-318 can be used to study pain-related disorders.

  • Eleclazine hydrochlo...

    A novel, potent, and selective inhibitor of Late sodium current (late INa) for treatment of long QT-3 syndrome (LQT-3).

  • Amiloride hydrochlor...

    A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.

Sign In Join Free