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Home - Products - Membrane Transporter/Ion Channel - Sodium Channel - PF-05150122

PF-05150122

CAS No. 1235406-03-7

PF-05150122 ( PF05150122 )

Catalog No. M10944 CAS No. 1235406-03-7

PF-05150122 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PF-05150122
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-05150122 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM.
  • Description
    PF-05150122 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.Pain Phase 1 Discontinued
  • Synonyms
    PF05150122
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Sodium Channel
  • Recptor
    Sodium Channel
  • Research Area
    Neurological Disease
  • Indication
    Pain

Chemical Information

  • CAS Number
    1235406-03-7
  • Formula Weight
    531.89
  • Molecular Formula
    C19H10ClF4N5O3S2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    5-chloro-2-fluoro-4-(2-(pyridazin-4-yl)-4-(trifluoromethyl)phenoxy)-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Swain NA, et al. J Med Chem. 2017 Aug 24;60(16):7029-7042.
2. Jones HM, et al. Clin Pharmacokinet. 2016 Jul;55(7):875-87.
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