Tetrodotoxin

Research use only, not for human use.

Tetrodotoxin (TTx) is a potent, highly selective sodium channel blocker with IC50 of 33 nM for Nav1.6.

Tetrodotoxin (TTx) is a potent, highly selective sodium channel blocker with IC50 of 33 nM for Nav1.6; Tetrodotoxin-sensitive sodium channel (Nav) family include Nav1.1, Nav1.2, Nav1.3, Nav1.4, Nav1.6, and Nav1.7, the Nav1.5, Nav1.8, and Nav1.9 channels are TTX-resistant; inhibits the firing of action potentials in neurons by binding to the voltage-gated sodium channels in nerve cell membranes and blocking the passage of sodium ions into the neuron.Pain Phase 3 Clinical.

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TTx

Membrane Transporter/Ion Channel

Sodium Channel

Sodium Channel

Neurological Disease

Pain

4368-28-9

319.268

C11H17N3O8

>98% (HPLC)

DMSO

NC1=N[C@H](O)[C@@]2([H])[C@]3([H])[C@](CO)(O)[C@]([H])([C@@]4([H])O)O[C@@](O)(O3)[C@@H](O)[C@@]24N1

5,9:7,10a-Dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol, 2-amino-1,4,4a,5,9,10-hexahydro-12-(hydroxymethyl)-, (4R,4aR,5R,7S,9S,10S,10aR,11S,12S)-

(-20℃)

With Ice Pack

≥ 2 years