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PF-04971729

CAS No. 1210344-57-2

PF-04971729( Ertugliflozin | MK-8835 | PF-4971729 )

Catalog No. M10784 CAS No. 1210344-57-2

A potent and selective SGLT2 inhibitor with IC50 of 0.877 nM for hSGLT2.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PF-04971729
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective SGLT2 inhibitor with IC50 of 0.877 nM for hSGLT2.
  • Description
    A potent and selective SGLT2 inhibitor with IC50 of 0.877 nM for hSGLT2; shows >2000-fold selectivity over hSGLT1; demonstrates robust urinary glucose excretion in rats and an excellent preclinical safety profile.Diabetes Phase 3 Clinical(In Vitro):Ertugliflozin (PF-04971729) demonstrates >2000-fold selectivity for SGLT2 inhibition (relative to SGLT1) in vitro.(In Vivo):Ertugliflozin (PF-04971729) reveals a concentration-dependent glucosuria after oral administration to rats.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Ertugliflozin | MK-8835 | PF-4971729
  • Pathway
    GPCR/G Protein
  • Target
    SGLT
  • Recptor
    SGLT2
  • Research Area
    Metabolic Disease
  • Indication
    Diabetes

Chemical Information

  • CAS Number
    1210344-57-2
  • Formula Weight
    436.8827
  • Molecular Formula
    C22H25ClO7
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 46 mg/mL
  • SMILES
    O[C@@H]1[C@](O2)(CO)CO[C@]2(C3=CC=C(Cl)C(CC4=CC=C(C=C4)OCC)=C3)[C@H](O)[C@H]1O
  • Chemical Name
    β-L-Idopyranose, 1,6-anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-5-C-(hydroxymethyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Mascitti V, et al. J Med Chem. 2011 Apr 28;54(8):2952-60. 2. Kalgutkar AS, et al. Drug Metab Dispos. 2011 Sep;39(9):1609-19. 3. Miao Z, et al. Drug Metab Dispos. 2013 Feb;41(2):445-56.
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