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Home - Products - Immunology/Inflammation - Lipoxygenase - PF-04191834

PF-04191834

CAS No. 1029317-21-2

PF-04191834( PF-4191834 )

Catalog No. M10139 CAS No. 1029317-21-2

PF-04191834 (PF-4191834) is a potent, non‐iron chelating, non‐redox, selective and competitive inhibitor of 5-lipoxygenase (5‐LO) with Ki of 10 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PF-04191834
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-04191834 (PF-4191834) is a potent, non‐iron chelating, non‐redox, selective and competitive inhibitor of 5-lipoxygenase (5‐LO) with Ki of 10 nM.
  • Description
    PF-04191834 (PF-4191834) is a potent, non‐iron chelating, non‐redox, selective and competitive inhibitor of 5-lipoxygenase (5‐LO) with Ki of 10 nM; displays 300‐fold over 12‐LO and 15‐LO, and no inhibition of the cyclooxygenase enzymes; is under clinical investigation for the oral treatment of asthma and pain.Pain Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PF-4191834
  • Pathway
    Immunology/Inflammation
  • Target
    Lipoxygenase
  • Recptor
    Lipoxygenase
  • Research Area
    Neurological Disease
  • Indication
    Pain

Chemical Information

  • CAS Number
    1029317-21-2
  • Formula Weight
    393.502
  • Molecular Formula
    C22H23N3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (254.13 mM)
  • SMILES
    O=C(C1(C2=CC=CC(SC3=CC=C(C4=CC=NN4C)C=C3)=C2)CCOCC1)N
  • Chemical Name
    4-(3-((4-(1-methyl-1H-pyrazol-5-yl)phenyl)thio)phenyl)tetrahydro-2H-pyran-4-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Masferrer JL, et al. J Pharmacol Exp Ther. 2010 Jul;334(1):294-301. 2. Rzodkiewicz P, et al. Reumatologia. 2016;54(4):161-164. Epub 2016 Oct 5.
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