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PF-03246799

CAS No. 1065110-62-4

PF-03246799( PF 03246799 | PF03246799 | PF-3246799 )

Catalog No. M10282 CAS No. 1065110-62-4

A potent and selective 5-HT2C receptor agonist with EC50 of 190 nM, with excellent selectivity for 5-HT2C over 5-HT2A.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    PF-03246799
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective 5-HT2C receptor agonist with EC50 of 190 nM, with excellent selectivity for 5-HT2C over 5-HT2A.
  • Description
    A potent and selective 5-HT2C receptor agonist with EC50 of 190 nM, with excellent selectivity for 5-HT2C over 5-HT2A; has minimal activation at either the 5-HT(2A) or 5-HT(2B) receptors, demonstrates robust efficacy in preclinical canine model of stress urinary incontinence (SUI) and attractive pharmacokinetic and safety properties.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PF 03246799 | PF03246799 | PF-3246799
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1065110-62-4
  • Formula Weight
    239.322
  • Molecular Formula
    C15H17N3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C12=NC(CC3=CC=CC=C3)=NC=C1CCNCC2
  • Chemical Name
    2-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-d]azepine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Andrews MD, et al. Bioorg Med Chem Lett. 2011 May 1;21(9):2715-20. 2. Dvorak CA, et al. ACS Med Chem Lett. 2015 Jul 20;6(9):1015-8.
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