PF-04781340 ( PF 04781340;PF04781340 )

Catalog No. M12519 CAS No. 1648726-56-0

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HNMR

HPLC

MSDS

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Product Name

PF-04781340
Note

Research use only, not for human use.
Brief Description

A potent, selective, CNS penetrant 5-HT2C receptor agonist with Ki of 3 nM and EC50 of 9 nM, without significant P-gp efflux liability.
Description

A potent, selective, CNS penetrant 5-HT2C receptor agonist with Ki of 3 nM and EC50 of 9 nM, without significant P-gp efflux liability; displays >150-fold selectivity over 5-HT2B receptors agonism (EC50=1484 nM); exhibits good metabolic stability in human liver microsomes (HLM) and moderate to good passive permeability in RRCK cells.
Synonyms

PF 04781340;PF04781340
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

5-HT Receptor
Research Area

——
Indication

——

CAS Number

1648726-56-0
Formula Weight

267.38
Molecular Formula

C17H21N3
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

3-benzyl-N-methyl-6,7,8,9-tetrahydro-5H-pyrido[3,4-d]azepin-1-amine

1. Dvorak CA, et al. ACS Med Chem Lett. 2015 Jul 20;6(9):1015-8.

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