PF-03049423 ( PF 03049423 )

Catalog No. M14380 CAS No. 402955-58-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

PF-03049423
Note

Research use only, not for human use.
Brief Description

PF-03049423 is a potent, selective, orally active, and brain penetrant inhibitor of PDE5 with IC50 of 0.2 nM.
Description

PF-03049423 is a potent, selective, orally active, and brain penetrant inhibitor of PDE5 with IC50 of 0.2 nM; displays 158-fold and 2460-fold selectivity over PDE6 and PDE11, respectively; possesses an excellent potency and selectivity profile and demonstrates robust in vivo blood pressure lowering in a spontaneously hypertensive rat (SHR) model.Stroke Phase 2 Discontinued
Synonyms

PF 03049423
Pathway

Angiogenesis
Target

PDE
Recptor

PDE
Research Area

Neurological Disease
Indication

Stroke

CAS Number

402955-58-2
Formula Weight

468.55
Molecular Formula

C24H32N6O4
Purity

>98% (HPLC)
Solubility

——
SMILES

CCCOCCN1C2=CC(=NC=C2N=C(C1=O)N3CCN(CC3)CCO)C4=CN=C(C=C4)OC.Cl
Chemical Name

3-[4-(2-Hydroxyethyl)-1-piperazinyl]-7-(6-methoxy-3-pyridinyl)-1-(2-propoxyethyl)-pyrido[3,4-b]pyrazin-2(1H)-one

1. Hughes RO, et al. J Med Chem. 2010 Mar 25;53(6):2656-60.
2. Di Cesare F, et al. J Stroke Cerebrovasc Dis. 2016 Mar;25(3):642-9.

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