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PF-03049423
CAS No. 402955-58-2
PF-03049423 ( PF 03049423 )
Catalog No. M14380 CAS No. 402955-58-2
PF-03049423 is a potent, selective, orally active, and brain penetrant inhibitor of PDE5 with IC50 of 0.2 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePF-03049423
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NoteResearch use only, not for human use.
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Brief DescriptionPF-03049423 is a potent, selective, orally active, and brain penetrant inhibitor of PDE5 with IC50 of 0.2 nM.
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DescriptionPF-03049423 is a potent, selective, orally active, and brain penetrant inhibitor of PDE5 with IC50 of 0.2 nM; displays 158-fold and 2460-fold selectivity over PDE6 and PDE11, respectively; possesses an excellent potency and selectivity profile and demonstrates robust in vivo blood pressure lowering in a spontaneously hypertensive rat (SHR) model.Stroke Phase 2 Discontinued
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SynonymsPF 03049423
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PathwayAngiogenesis
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TargetPDE
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RecptorPDE
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Research AreaNeurological Disease
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IndicationStroke
Chemical Information
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CAS Number402955-58-2
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Formula Weight468.55
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Molecular FormulaC24H32N6O4
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Purity>98% (HPLC)
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Solubility——
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SMILESCCCOCCN1C2=CC(=NC=C2N=C(C1=O)N3CCN(CC3)CCO)C4=CN=C(C=C4)OC.Cl
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Chemical Name3-[4-(2-Hydroxyethyl)-1-piperazinyl]-7-(6-methoxy-3-pyridinyl)-1-(2-propoxyethyl)-pyrido[3,4-b]pyrazin-2(1H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Hughes RO, et al. J Med Chem. 2010 Mar 25;53(6):2656-60.
2. Di Cesare F, et al. J Stroke Cerebrovasc Dis. 2016 Mar;25(3):642-9.
2. Di Cesare F, et al. J Stroke Cerebrovasc Dis. 2016 Mar;25(3):642-9.
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